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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2020; 78(02): 70-75
DOI: 10.1590/0004-282X20190136
ARTICLE

Can fatigue predict walking capacity of patients with Parkinson’s disease?

A fadiga pode predizer a mobilidade e a capacidade de marcha em pacientes com doença de Parkinson?
Davi Vilela CARVALHO 
1   Universidade Federal de Minas Gerais, Programa de Pós-Graduação em Neurociências, Belo Horizonte MG, Brazil.
,
Renata Maria Silva SANTOS 
2   Universidade Federal de Minas Gerais, Programa de Pós-Graduação em Patologia, Belo Horizonte MG, Brazil.
,
Helen Cardoso de MAGALHÃES 
3   Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Belo Horizonte MG, Brazil.
,
Mariana Soares de SOUZA 
4   Santa Casa de Belo Horizonte, Centro de Especialidades Médicas, Belo Horizonte MG, Brazil.
,
Paulo Pereira CHRISTO 
4   Santa Casa de Belo Horizonte, Centro de Especialidades Médicas, Belo Horizonte MG, Brazil.
,
Camila Megale de ALMEIDA-LEITE 
5   Instituto de Ciências Biológicas, Departamento de Morfologia, Belo Horizonte MG, Brazil.
,
Paula Luciana SCALZO 
5   Instituto de Ciências Biológicas, Departamento de Morfologia, Belo Horizonte MG, Brazil.
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ABSTRACT

Although fatigue is an expressive symptom of Parkinson’s disease (PD), few studies have investigated the association between fatigue, mobility and walking capacity of these patients. Objective: To investigate whether fatigue is an independent factor associated with mobility and the walking capacity in patients with PD. Methods: Forty-eight patients with PD (22 with fatigue) were tested for mobility and their walking capacity: Timed Up and Go (TUG), 10-Meter Walk Test (10MWT) at usual and fastest speed, and 6-Minute Walk Test (6MWT). Fatigue was measured with Parkinson’s Fatigue Scale (PFS-16). Linear regression analysis was used to investigate if fatigue is an independent factor contributing to variance in mobility and walking capacity. Results: There was a positive correlation between PFS-16 and TUG (rs=0.385; p=0.007). There was a negative correlation between PFS-16 and 10MWT at comfortable (r=-0.385; p=0.007) and fast speeds (r=-0.396; p=0.005), and 6MWT (r=-0.472; p=0.001). Linear regression analysis revealed that fatigue did not explain the variance of TUG and 10MWT. PFS-16, age and section III of UPDRS explained 49.6% (adjusted R2; p<0.001) variance in the 6MWT, and fatigue was the most significant predictor (F=-32.1; p=0.022). Conclusions: Fatigue is an independent factor contributing to the distance covered during 6MWT in patients with PD. Our results highlight the importance of recognition and management of this symptom.

RESUMO

Embora a fadiga seja um sintoma importante na doença de Parkinson (DP), poucos estudos investigaram a associação entre fadiga, mobilidade e capacidade de marcha nesses pacientes. Objetivo: Investigar se a fadiga é um fator independente associado à mobilidade e à capacidade de marcha em pacientes com DP. Métodos: Quarenta e oito pacientes com DP (22 com fadiga) foram avaliados com testes de mobilidade e capacidade de marcha: Timed Up and Go (TUG), Teste de Caminhada de 10 metros (T10m) na velocidade usual e máxima, Teste de Caminhada de Seis Minutos (TC6m). A fadiga foi medida pela Escala de Fadiga no Parkinson (PFS-16). A análise de regressão linear foi utilizada para investigar se a fadiga é um fator independente que contribui para a variação na mobilidade e capacidade de marcha. Resultados: Houve correlação positiva entre PFS-16 e TUG (rs=0,385; p=0,007). Houve correlação negativa entre PFS-16 e T10m na velocidade usual (r=-0,385; p=0,007) e máxima (r=-0,396; p=0,005) e TC6m (r=-0,472; p=0,001). Análise de regressão linear revelou que a fadiga não explicava a variância do TUG e T10m. A PFS-16, a idade e a seção III da UPDRS explicaram 49,6% (R2 ajustado, p<0,001) da variância no TC6m e a fadiga foi o preditor mais significativo (F=-32,1; p=0,022). Conclusões: A fadiga é um fator independente que contribui para a distância percorrida durante o TC6m em pacientes com DP. Nossos resultados destacam a importância do reconhecimento e manejo desse sintoma.

Keywords:

Parkinson’s disease - fatigue - mobility - gait speed - walking capacity

Palavras-chave:

doença de Parkinson - fadiga - mobilidade - velocidade de marcha - capacidade de marcha


Publication History

Received: 30 July 2019

Accepted: 09 September 2019

Article published online:
13 June 2023

© 2020. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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