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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2019; 77(04): 248-253
DOI: 10.1590/0004-282X20190035
Article

Disability as a determinant of fatigue in MS patients

Incapacidade como determinante da fadiga em pacientes com EM
Fernanda M. Taveira 
1   Universidade Federal de Minas Gerais, Programa de Pós-graduação em Neurociências, Belo Horizonte MG, Brasil
,
Nayara F. T. Braz
1   Universidade Federal de Minas Gerais, Programa de Pós-graduação em Neurociências, Belo Horizonte MG, Brasil
2   Universidade Federal de Minas Gerais, Escola de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil
,
Elizabeth R. Comini-Frota
1   Universidade Federal de Minas Gerais, Programa de Pós-graduação em Neurociências, Belo Horizonte MG, Brasil
,
Antçnio L. Teixeira
1   Universidade Federal de Minas Gerais, Programa de Pós-graduação em Neurociências, Belo Horizonte MG, Brasil
2   Universidade Federal de Minas Gerais, Escola de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil
,
Renan B. Domingues
1   Universidade Federal de Minas Gerais, Programa de Pós-graduação em Neurociências, Belo Horizonte MG, Brasil
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ABSTRACT

Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue.

Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment.

Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue.

Results: Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p < 0.05).

Conclusions: The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not.

RESUMO

A fadiga é um dos sintomas mais frequentes e incapacitantes na esclerose múltipla (EM). Fatores centrais, psicológicos e periféricos podem contribuir para a ocorrência de fadiga.

Objetivos: O presente estudo teve como objetivo avaliar potenciais determinantes de fadiga em pacientes com EM remitente-recorrente (EMRR) com baixo nível de incapacidade funcional.

Métodos: Foram comparados marcadores inflamatórios, pressões respiratórias, incapacidade e qualidade de vida em 39 pacientes com EMRR com e sem fadiga.

Resultados: Pacientes com EMRR com fadiga apresentaram maior Escala de Incapacidade Funcional Expandida (p = 0,002). Observamos uma associação significativa entre os resultados da Escala de Incapacidade Neurológica de Guy e Escala de Avaliação da Qualidade de Vida Funcional com a presença de fadiga (valores de p < 0,05).

Conclusão: O grau de comprometimento funcional, mas não a função respiratória e os marcadores inflamatórios, são determinantes para a presença de fadiga em pacientes com EM.

Keywords:

Multiple sclerosis - fatigue - inflammation

Palavras-chave:

Esclerose múltipla - fadiga - inflamação

Support

This work was partly funded by Fapemig and CNPq, Brazilian Government funding agencies.




Publication History

Received: 10 September 2018

Accepted: 09 January 2019

Article published online:
16 August 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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