Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

Yousef Baghcheghi; Mahmoud Hosseini; Farimah Beheshti; Hossein Salmani; Akbar Anaeigoudari

doi:10.1590/0004-282X20170182

Arquivos de Neuro-Psiquiatria, Table of Contents

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2018; 76(01): 32-40
DOI: 10.1590/0004-282X20170182

ARTICLE

Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

Timoquinona protegeu contra deficiências de aprendizagem e memória e danos nos tecidos cerebrais em ratos hipotireoidais juvenis

Yousef Baghcheghi

¹Mashhad University of Medical Sciences, Faculty of Medicine, Department of Physiology, Student Research Committee, Mashhad, Iran;

,

Mahmoud Hosseini

²Mashhad University of Medical Sciences, Psychiatry and Behavioral Sciences Research Center, Division of Neurocognitive Sciences, Mashhad, Iran;

,

Farimah Beheshti

³Torbat Heydariyeh University of Medical Sciences, Department of Basic Science and Neuroscience Research Center, Torbat Heydariyeh, Iran;

,

Hossein Salmani

⁴Mashhad University of Medical Sciences, Faculty of Medicine, Department of Physiology, Mashhad, Iran;

,

Akbar Anaeigoudari

⁵Jiroft University of Medical Sciences, School of Medicine, Department of Physiology, Jiroft, Iran.

› Author Affiliations

Abstract

ABSTRACT

In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.

RESUMO

Neste estudo, foi investigado o efeito da timoquinona (TQ) contra deficiências de memória induzidas por propiltiouracilo (PTU) em ratos juvenis. Os ratos foram agrupados em grupos: controle, Hypo, Hypo-TQ5, e Hypo-TQ10. O PTU aumentou o tempo de latência no teste do labirinto aquático de Morris (MWM) e diminuiu o atraso para entrar no compartimento escuro no teste de evasão passiva (PA). Ambas as doses de TQ diminuíram o tempo de latência no teste de MWM e aumentaram o atraso para entrar no compartimento escuro no teste de PA. O PTU também aumentou os metabolitos de malondialdeído (MDA) e óxido nítrico (NO) no cérebro, enquanto reduziu o teor de tiol e as atividades de superóxido dismutasa (SOD) e catalasa (CAT) e o nível sérico de T4. Ambas as doses de TQ diminuíram os metabolitos de MDA e de NO no cérebro, aumentaram o conteúdo de tiol e as atividades de SOD e CAT e o nível de T4 no soro. Os resultados do presente estudo mostraram que a TQ protegeu contra deficiências de memória induzidas por PTU em ratos.

hypothyroidism - propylthiouracil - memory

hipotireoidismo - propiltiouracila - memória

Full Text

References

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