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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(06): 470-477
DOI: 10.1590/0004-282X20160070
ARTICLES

Impaired executive functions in experimental model of temporal lobe epilepsy

Prejuízo das funções executivas no modelo experimental de epilepsia do lobo temporal
Fabiane Ochai Ramos
1   Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, Programa de Pós-Graduação em Distúrbios do Desenvolvimento, São Paulo SP, Brasil;
2   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
,
Luiz Renato Rodrigues Carreiro
1   Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, Programa de Pós-Graduação em Distúrbios do Desenvolvimento, São Paulo SP, Brasil;
,
Fulvio Alexandre Scorza
2   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
,
Roberta Monterazzo Cysneiros
1   Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, Programa de Pós-Graduação em Distúrbios do Desenvolvimento, São Paulo SP, Brasil;
› Author AffiliationsSupported: This work was sponsored by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-302528/2011-3) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP-2011/50680-2). Fabiane Ochai Ramos was fellow from CNPq.
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ABSTRACT

Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE).

Method Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal.

Results Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory.

Conclusion Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior.

RESUMO

Objetivo O presente estudo teve como objetivo investigar as alterações cognitivas e comportamentais consistentes com o comportament de transtorno de deficit de atenção e hiperatividade (TDAH) -like em ratos Wistar machos com epilepsia do lobo temporal (ELT).

Método Ratos Wistar machos com 25 dias de vida foram submetidos a modelo animal de ELT pela injeção de pilocarpina (350 mg / kg, ip) e grupo controle recebeu salina 0,9%. Os animais foram monitorados continuamente por vídeo até ao final dos experimentos. Os testes comportamentais (campo aberto, labirinto em cruz elevado e caixa de condicionamento operante) começaram a partir de 60 dias pós-natal.

Resultados Os animais com ELT exibiram aumento da atividade locomotora, redução do comportamento relacionado com a ansiedade, impulsividade e prejuízo da memória de trabalho visuospatial.

Conclusão Em conjunto, concluímos que os animais com ELT apresentaram algumas alterações cognitivas e comportamentais consistentes com o comportamento TDAH-like.

Epilepsy, temporal lobe - executive function - pilocarpine - memory, short-term
epilepsia do lobo temporal - função executiva - pilocarpina - memória de curto prazo

Support:

Supported: This work was sponsored by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-302528/2011-3) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP-2011/50680-2). Fabiane Ochai Ramos was fellow from CNPq.




Publication History

Received: 11 November 2015

Accepted: 15 March 2016

Article published online:
06 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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