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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(04): 307-313
DOI: 10.1590/0004-282X20160032
ARTICLE

Twin-twin transfusion syndrome: neurodevelopment of infants treated with laser surgery

Síndrome de transfusão feto-fetal: neurodesenvolvimento de lactentes tratados com cirurgia a laser
Denise Campos
1   Universidade Estadual de Campinas,Departamento de NeurologiaeCentro de Investigação em Pediatria,CampinasSP,Brazil;
,
Amabile V. Arias
1   Universidade Estadual de Campinas,Departamento de NeurologiaeCentro de Investigação em Pediatria,CampinasSP,Brazil;
,
Thatiane M. Campos-Zanelli
1   Universidade Estadual de Campinas,Departamento de NeurologiaeCentro de Investigação em Pediatria,CampinasSP,Brazil;
,
Daniela S. Souza
1   Universidade Estadual de Campinas,Departamento de NeurologiaeCentro de Investigação em Pediatria,CampinasSP,Brazil;
,
Orlando G. dos Santos Neto
2   Universidade Estadual de Campinas,Departamento de Obstetrícia e GinecologiaeHospital da Mulher Prof. Dr. José Aristodemo Pinotti,CampinasSP,Brazil.
,
Cleisson Fabio A. Peralta
2   Universidade Estadual de Campinas,Departamento de Obstetrícia e GinecologiaeHospital da Mulher Prof. Dr. José Aristodemo Pinotti,CampinasSP,Brazil.
,
Marilisa M. Guerreiro
1   Universidade Estadual de Campinas,Departamento de NeurologiaeCentro de Investigação em Pediatria,CampinasSP,Brazil;
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ABSTRACT

Objective To assess the neurodevelopmental functions of survivors of twin-twin transfusion syndrome (TTTS) treated by fetoscopic laser coagulation (FLC), during the first year of life, comparing them to a control group; and to verify the influence of specific variables on neurodevelopment.

Method This was a prospective, longitudinal study. The sample comprised 33 monochorionic diamniotic twins who underwent FLC for treatment of TTTS and 22 full-term infants of single-fetus pregnancies. Bayley Scales of Infant and Toddler Development Screening Test were used for evaluation. Prenatal, perinatal and postnatal information were obtained.

Results There was an increased frequency of infants in the TTTS group with inadequate performance compared to the control group. The identified variables (fetal donor, low economic income and cardiorespiratory disease) negatively impacted expressive communication and fine motor skills.

Conclusion Although through follow-up is recommended in all TTTS survivors, particular attention is required for the high-risk group as defined in this study.

RESUMO

Objetivo Avaliar o desenvolvimento neurológico de sobreviventes da sindrome de transfusão feto-fetal (STFF) submetidos à coagulação a laser por fetoscopia (CLF), durante o primeiro ano de vida, comparando estes ao grupo controle; e verificar a influência de variáveis específicas no desenvolvimento.

Método Tratou-se de estudo prospectivo, longitudinal. A amostra foi composta por 33 gêmeos diamnióticos monocoriçnicos submetidos à CLF para tratamento da STFF e 22 lactentes a termo de gestação única. Bayley Scales of Infant and Toddler Development Screening Test foram utilizadas para avaliação. Informações pré-natal, perinatal e pós-natal foram coletadas.

Resultados Houve maior número de lactentes com desempenho inadequado no grupo STFF do que no controle. As variáveis identificadas (feto doador, baixa renda econçmica e doença cárdio-respiratória) influenciaram negativamente a comunicação expressiva e as habilidades motoras finas.

Conclusão Embora o acompanhamento seja recomendado para todos lactentes com STFF, especial atenção deve ser dada àqueles que apresentam fatores de risco.

diseases in twins - fetofetal transfusion - child development - risk factors
doenças em gêmeos - transfusão feto-fetal - desenvolvimento infantil - fatores de risco


Publikationsverlauf

Eingereicht: 14. Juli 2015

Angenommen: 30. November 2015

Artikel online veröffentlicht:
06. September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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