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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2021; 79(12): 1070-1075
DOI: 10.1590/0004-282X-ANP-2020-0219
Articles

ABO blood group system and occurrence of ischemic stroke

Sistema ABO de grupos sanguíneos e ocorrência de acidente vascular cerebral isquêmico
Rafaella Chiodini LOTZ 
1   Universidade da Região de Joinville, Departamento de Medicina, Joinville SC, Brazil.
,
Carolina da Silveira WELTER 
1   Universidade da Região de Joinville, Departamento de Medicina, Joinville SC, Brazil.
,
Silvia Aparecida RAMOS 
1   Universidade da Região de Joinville, Departamento de Medicina, Joinville SC, Brazil.
,
Leslie Ecker FERREIRA 
1   Universidade da Região de Joinville, Departamento de Medicina, Joinville SC, Brazil.
2   Universidade da Região de Joinville, Joinville Stroke Biobank, Joinville SC, Brazil.
,
Norberto Luiz CABRAL 
1   Universidade da Região de Joinville, Departamento de Medicina, Joinville SC, Brazil.
2   Universidade da Região de Joinville, Joinville Stroke Biobank, Joinville SC, Brazil.
3   Hospital Municipal São José, Serviço de Neurologia, Joinville SC, Brazil.
,
Paulo Henrique Condeixa de FRANÇA 
1   Universidade da Região de Joinville, Departamento de Medicina, Joinville SC, Brazil.
2   Universidade da Região de Joinville, Joinville Stroke Biobank, Joinville SC, Brazil.
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ABSTRACT

Background: Ischemic stroke (IS) is a multifactorial disease that presents high rates of morbimortality in Brazil. Several studies proved that there is a link between the ABO blood group system and the occurrence of thrombotic events. Nonetheless, its association with IS is not well established. Objective: For that reason, the purpose hereof was to investigate the relation between the ABO blood groups and the occurrence of IS in a Brazilian cohort of cerebrovascular diseases. Methods: Five hundred and twenty-nine subjects were included over 12 months, from which 275 presented an IS episode and 254 composed the control group. Blood samples were drawn for direct and reverse serotyping. The control and IS groups were compared regarding the traditional risk factors and the distribution of the ABO blood groups. Results: The IS group presented a higher prevalence of systemic arterial hypertension (SAH), diabetes mellitus, smoking habits, family history, cardiopathy, and sedentary lifestyle in comparison with the control group. The AB blood type prevailed among the patients (5.1 vs. 1.6%; p<0.05) and this group had more SAH cases in comparison with the O type group (92.9 vs. 67.3%; p<0.05). Conclusions: Our results suggest that the occurrence of IS is more frequent among patients of the AB blood type.

RESUMO

Antecedentes: O acidente vascular cerebral isquêmico (AVCI) é uma doença multifatorial que apresenta altas taxas de morbimortalidade no Brasil. Vários estudos provaram que existe uma ligação entre o sistema ABO de grupos sanguíneos e a ocorrência de eventos trombóticos. No entanto, sua associação com AVCI não está bem estabelecida. Objetivo: Por essa razão, o objetivo deste trabalho foi investigar a relação entre os grupos sanguíneos ABO e a ocorrência de AVCI em uma coorte brasileira de doenças cerebrovasculares. Métodos: Ao longo de 12 meses foram incluídos 529 indivíduos, dos quais 275 apresentaram um episódio de AVCI e 254 compuseram o grupo controle. Amostras de sangue foram coletadas para sorotipagem direta e reversa. Os grupos controle e AVCI foram comparados em relação aos fatores de risco tradicionais e à distribuição dos grupos sanguíneos ABO. Resultados: O grupo AVCI apresentou maior prevalência de hipertensão arterial sistêmica (HAS), diabetes mellitus, tabagismo, história familiar, cardiopatia e estilo de vida sedentário em comparação ao grupo controle. O tipo sanguíneo AB prevaleceu entre os pacientes (5,1 vs. 1,6%; p<0,05) e apresentou mais casos de HAS em comparação ao tipo O (92,9 vs. 67,3%; p<0,05). Conclusões: Nossos resultados sugerem que a ocorrência de AVCI é mais frequente entre os pacientes do tipo sanguíneo AB.

Keywords:

Ischemic Stroke - ABO Blood-Group System - Risk Factors

Palavras-chave:

AVC Isquêmico - Sistema ABO de Grupos Sanguíneos - Fatores de Risco

Authors’ contributions:

RCL, CSW: conceived and designed the research, acquired the data, analyzed and interpreted the data and drafted the manuscript; SAR: conceived and designed the research, handled supervision, analyzed and interpreted the data; LEF, NLC: analyzed and interpreted the data and made critical revision of the manuscript for important intellectual content; PHCF: conceived and designed the research, handled supervision, analyzed and interpreted the data and made critical revision of the manuscript for important intellectual content.


Support:

This work was supported by the Research Support Fund from the Universidade da Região de Joinville (INVITATION LETTER Nº 02/16 - Call for Projects Linked to Stricto Sensu Programs).




Publication History

Received: 03 June 2020

Accepted: 11 January 2021

Article published online:
07 June 2023

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