Tierarztl Prax Ausg K Kleintiere Heimtiere 2018; 46(05): 315-322
DOI: 10.15654/TPK-180089
Übersichtsartikel – Review Article
Georg Thieme Verlag KG Stuttgart · New York

Update on therapy and prevention of canine leishmaniasis

Article in several languages: deutsch | English
Neoklis Apostolopoulos
1  AniCura Kleintierspezialisten Augsburg GmbH, Augsburg
,
Athanasia Mitropoulou
2  Klinik für Kleintiere – Innere Medizin, Justus-Liebig-Universität Gießen
,
Nina Thom
2  Klinik für Kleintiere – Innere Medizin, Justus-Liebig-Universität Gießen
,
Andreas Moritz
2  Klinik für Kleintiere – Innere Medizin, Justus-Liebig-Universität Gießen
› Author Affiliations
Further Information

Publication History

Eingegangen: 10 January 2018

Akzeptiert nach Revision: 28 July 2018

Publication Date:
12 December 2018 (online)

Summary

Canine leishmaniasis is an emerging infection with increasing importance because the main vector also exists in Germany and autochthonous infections have been described. In this article we present the latest information available regarding therapy and prevention of this disease. Allopurinol-resistant Leishmania infantum strains were isolated from dogs which experienced recurrent disease while being treated with allopurinol, highlighting the need for alternative treatment options. Differing results of long-term studies on the efficacy of miltefosine in combination with allopurinol in comparison to meglumine antimoniate and allopurinol can affect the selection of the treatment protocol. A high number of repellents with distinctive characteristics is available for the prevention of infection in dogs. In Europe, two vaccines are licensed for dogs which aim at reducing the risk of an active infection and the severity clinical disease.