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Tierarztl Prax Ausg K Kleintiere Heimtiere 2018; 46(01): 49-56
DOI: 10.15654/TPK-161024
Für Studium und Praxis
Schattauer GmbH

Feline Panleukopenie – die wichtige Rolle von Antikörpern

Feline panleukopenia – the important role of antibodies
Anna-Lena Proksch
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
,
Katherina Mende
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
,
Michèle Bergmann
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
,
Katrin Hartmann
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
› Author Affiliations
Further Information

Publication History

Eingegangen: 07 November 2016

Akzeptiert nach Revision: 26 September 2017

Publication Date:
21 February 2018 (online)

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Zusammenfassung

Die feline Panleukopenie zählt zu den wichtigsten Infektionskrankheiten der Katze. Jede Katze sollte zuverlässig vor Panleukopenie geschützt sein. Eine erfolgreiche Grundimmunisierung ist für die Ausbildung einer belastbaren Immunität essenziell. Panleukopenie tritt nach wie vor häufig auf und betrifft vor allem Katzenwelpen. Maternale Antikörper spielen eine wichtige Rolle für den Schutz der Welpen. Aufgrund ihres langen Fortbestehens, teilweise bis zur 20. Lebenswoche, können maternale Antikörper jedoch mit der Impfung interferieren und den Aufbau einer belastbaren Immunität verhindern. So kannes trotz Impfung zu Erkrankungen kommen. Bei adulten Katzen mit chronischer Krankheit oder Immunsuppression kann die Immunantwort nach einer Impfung reduziert sein. Etwa 30% aller adulten Katzen haben keine Antikörper. Die Bestimmung des Antikörpertiters bei Welpen ermöglicht die Berechnung des optimalen Zeitpunkts für eine erfolgreiche Grundimmunisierung. Bei adulten Tieren bietet die Titerbestimmung eine Alternative, um unnötige Impfungen zu vermeiden und ein individuelles Impfschema zu ermitteln. Nur Katzen ohne Antikörper sollten geimpft werden. Zur Bestimmung des Antikörpertiters steht für die Praxis ein leicht durchführbarer Schnelltest zur Verfügung.

Summary

Feline panleukopenia is an important infectious disease. Despite vaccination, panleukopenia remains common, particularly in young kittens. Development of active immunity after primary vaccination is essential for protection. Therefore, vaccination against panleukopenia is a core vaccine. Efficacy of primary vaccination can be reduced by maternally derived antibodies that can persist up to 20 weeks and interfere with the vaccination. In adult cats, antibody development after vaccination can be reduced during chronic disease or immunosuppression. Approximately 30% of adult cats lack antibodies. Evaluation of antibody titres in kittens enables calculation of the ideal time point to initiate primary vaccinations with the goal to establish effective immunity. In adult cats, evaluation of antibody titres is a useful alternative to avoid unnecessary vaccinations and to create an individual vaccination schedule. Only cats lacking antibodies should be vaccinated. Evaluation of antibodies in private practice can be performed using a rapid in-house test.

SchlüsselWörter

Katze - felines Parvovirus - Impfung - Schnelltest - Hämmagglutinations-hemmtest - ELISA - Titer

Keywords

Cat - feline parvovirus - vaccination - rapid in-house test - haemagglutination inhibition - ELISA - titre
 

  • Literatur

  • 1 Bergmann M, Friedl Y, Hartmann K. Passive Immunisierung bei Hund und Katze. Tierärztl Prax 2016; 44 (K): 287-292.
    PubMedGoogle Scholar
  • 2 Blanco K, Prendas J, Cortes R, Jimenez C, Dolz G. Seroprevalence of viral infections in domestic cats in Costa Rica. J Vet Med Sci 2009; 71: 661-663.
    CrossrefPubMedGoogle Scholar
  • 3 Brun A, Chappuis G, Precausta P, Terre J. Immunisation against panleu-kopenia: early development of immunity. Comp Immunol Microbiol Infect Dis 1979; 01: 335-339.
    CrossrefPubMedGoogle Scholar
  • 4 Casseleux G, Fontaine E. Gestion de la parvovirose en elevage canin. Point Veterinaire 2006; 37: 42-46.
    PubMedGoogle Scholar
  • 5 Chalmers WS, Truyen U, Greenwood NM, Baxendale W. Efficacy of feline panleucopenia vaccine to prevent infection with an isolate of CPV2b obtained from a cat. Vet Microbiol 1999; 69: 41-45.
    CrossrefPubMedGoogle Scholar
  • 6 Claus MA, Levy JK, MacDonald K, Tucker SJ, Crawford PC. Immunoglobulin concentrations in feline colostrum and milk, and the requirement of colostrum for passive transfer of immunity to neonatal kittens. J Feline Med Surg 2006; 08: 184-191.
    CrossrefPubMedGoogle Scholar
  • 7 Dawson S, Willoughby K, Gaskell RM, Wood G, Chalmers WS. A field trial to assess the effect of vaccination against feline herpesvirus, feline calicivirus and feline panleucopenia virus in 6-week-old kittens. J Feline Med Surg 2001; 03: 17-22.
    CrossrefPubMedGoogle Scholar
  • 8 Day M. What we need to know about vaccination and titre testing. British Small Animal Veterinary Association Congress 2012, Birmingham..
    PubMedGoogle Scholar
  • 9 Day M. Utility of serum antibody assays to monitor protection and the need for vaccination. Pre-Congress Symposium, European College of Veterinary Internal Medicine 2013, Liverpool..
    PubMedGoogle Scholar
  • 10 Day MJ, Schoon HA, Magnol JP, Saik J, Devauchelle P, Truyen U, Gruffydd-Jones TJ, Cozette V, Jas D, Poulet H, Pollmeier M, Thibault JC. A kinetic study of histopathological changes in the subcutis of cats injected with non-adjuvanted and adjuvanted multi-component vaccines. Vaccine 2007; 25: 4073-4084.
    CrossrefPubMedGoogle Scholar
  • 11 Day MJ, Horzinek MC, Schultz RD. WSAVA guidelines for the vaccination of dogs and cats. J Small Anim Pract 2010; 51: 1-32.
    PubMedGoogle Scholar
  • 12 Digangi BA, Levy JK, Griffin B, Reese MJ, Dingman PA, Tucker SJ, Dubovi EJ. Effects of maternally-derived antibodies on serologic responses to vaccination in kittens. J Feline Med Surg 2012; 14: 118-123.
    CrossrefPubMedGoogle Scholar
  • 13 DiGangi BA, Gray LK, Levy JK, Dubovi EJ, Tucker SJ. Detection of protective antibody titers against feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus in shelter cats using a point-of-care ELISA. J Feline Med Surg 2011; 13: 912-918.
    CrossrefPubMedGoogle Scholar
  • 14 Erhardt W. [Use of passive and active vaccines against panleukopenia in cats]. Berl Munch Tierarztl Wochenschr 1977; 90: 337-340.
    PubMedGoogle Scholar
  • 15 Franchini M. Die Tollwutimpfung von mit felinem Leukämievirus infi-zierten Katzen. Dissertation, Universität Zürich. 1990
    PubMedGoogle Scholar
  • 16 Friedrich K, Truyen U. Untersuchungen der Wirksamkeit von Parvovirus -impfstoffen und der Effektivitäg zweier Impfschemata. Prakt Tierarzt 2000; 12: 988-994.
    PubMedGoogle Scholar
  • 17 Gamoh K, Senda M, Inoue Y, Itoh O. Efficacy of an inactivated feline pan-leucopenia virus vaccine against a canine parvovirus isolated from a domestic cat. Vet Rec 2005; 157: 285-287.
    CrossrefPubMedGoogle Scholar
  • 18 Gerlach M, Proksch AL, Unterer S, Speck S, Truyen U, Hartmann K. Efficacy of feline anti-parvovirus antibodies in the treatment of canine parvovirus infection. J Small Anim Pract 2017; 58 (07) 408-415.
    CrossrefPubMedGoogle Scholar
  • 19 Gore TC, Lakshmanan N, Williams JR, Jirjis FF, Chester ST, Duncan KL, Coyne MJ, Lum MA, Sterner FJ. Three-year duration of immunity in cats following vaccination against feline rhinotracheitis virus, feline calicivirus, and feline panleukopenia virus. Vet Ther 2006; 07: 213-222.
    PubMedGoogle Scholar
  • 20 Greene C. ed. Feline parvovirus infection. In: Infectious Diseases of the Dog and the Cat. Philadelphia: Saunders; 2012: 80-88.
    Google Scholar
  • 21 Greene CE, Levy JK. Immunoprophylaxis. In: Infectious Diseases of the Dog and Cat. 4th edn.. Greene CE. ed. St. Louis, MO: Elsevier Saunders; 2012: 1163-1205.
    Google Scholar
  • 22 Greene CE, Addie DD. Feline parvovirus infection. In: Infectious Diseases of the Dog and Cat. Greene CE. ed. Philadelphia: Saunders; 2006: 80-88.
    Google Scholar
  • 23 Hanson BJ, Boon AC, Lim AP, Webb A, Ooi EE, Webby RJ. Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice. Respir Res 2006; 07: 126.
    CrossrefPubMedGoogle Scholar
  • 24 Hartmann K, Day MJ, Thiry E, Lloret A, Frymus T, Addie D, Boucraut-Baralon C, Egberink H, Gruffydd-Jones T, Horzinek MC, Hosie MJ, Lutz H, Marsilio F, Pennisi MG, Radford AD, Truyen U, Mostl K. Feline injection-site sarcoma: ABCD guidelines on prevention and management. J Feline Med Surg 2015; 17: 606-613.
    CrossrefPubMedGoogle Scholar
  • 25 Hartmann K, Kohn B, Moritz A, Schulte K, Steidl T, Straubinger R, Truyen U. Ständige Impfkommision Veterinär (StiKo Vet). Leitlinie zur Impfung von Kleintieren. 2017
    PubMedGoogle Scholar
  • 26 Hellard E, Fouchet D, Santin-Janin H, Tarin B, Badol V, Coupier C, Leblanc G, Poulet H, Pontier D. When cats’ ways of life interact with their viruses: a study in 15 natural populations of owned and unowned cats (Felis silvestris catus). Prev Vet Med 2011; 101: 250-264.
    CrossrefPubMedGoogle Scholar
  • 27 Hoffmann A, Schönborn E, Mergel A, Cußler K. Pharmakovigilanzreport Tierimpfstoffe, Analyse der im Jahr 2008 und 2009 im Paul-Ehrlich-Institut eingegangenen Meldungen. Deutsches Tierärzteblatt 2010; 06: 766-775.
    PubMedGoogle Scholar
  • 28 Horzinek MC, Thiry E. Vaccines and vaccination: the principles and the polemics. J Feline Med Surg 2009; 11: 530-537.
    CrossrefPubMedGoogle Scholar
  • 29 Jakel V, Cussler K, Hanschmann KM, Truyen U, König M, Kamphuis E, Duchow K. Vaccination against Feline Panleukopenia: Implications from a field study in kittens. BMC Vet Res 2012; 08: 62.
    CrossrefPubMedGoogle Scholar
  • 30 Jas D, Aeberlé C, Lacombe V, Guiot AL, Poulet H. Onset of immunity in kittens after vaccination with a non-adjuvanted vaccine against feline pan-leucopenia, feline calicivirus and feline herpesvirus. Vet J 2009; 182: 86-93.
    CrossrefPubMedGoogle Scholar
  • 31 Kruse BD, Unterer S, Horlacher K, Sauter-Louis C, Hartmann K. Prognostic factors in cats with feline panleukopenia. J Vet Intern Med 2010; 24: 1271-1276.
    CrossrefPubMedGoogle Scholar
  • 32 Kruse BD, Unterer S, Horlacher K, Sauter-Louis C, Hartmann K. Feline Panleukopenie – differierender Krankheitsverlauf bei Katzen im Alter von unter bzw. über 6 Monaten?. Tierärztl Prax 2011; 39 (K): 237-242.
    PubMedGoogle Scholar
  • 33 Lappin MR, Andrews J, Simpson D, Jensen WA. Use of serologic tests to predict resistance to feline herpesvirus 1, feline calicivirus, and feline parvovirus infection in cats. J Am Vet Med Assoc 2002; 220: 38-42.
    CrossrefPubMedGoogle Scholar
  • 34 Lappin MR. Feline panleukopenia virus, feline herpesvirus-1 and feline cali civirus antibody responses in seronegative specific pathogen-free kittens after parenteral administration of an inactivated FVRCP vaccine or a mo -dified live FVRCP vaccine. J Feline Med Surg 2012; 14: 161-164.
    CrossrefPubMedGoogle Scholar
  • 35 Levy JK, Crawford PC, Lappin MR, Dubovi EJ, Levy MG, Alleman R, Tucker SJ, Clifford EL. Infectious diseases of dogs and cats on Isabela Island, Galapagos. J Vet Intern Med 2008; 22: 60-65.
    CrossrefPubMedGoogle Scholar
  • 36 Luff PR, Wood GW, Hebert CN, Thornton DH. Canine parvovirus serology: a collaborative assay. Vet Rec 1987; 120: 270-273.
    CrossrefPubMedGoogle Scholar
  • 37 Macartney L, Thompson H, McCandlish IA, Cornwell HJ. Canine parvovirus: interaction between passive immunity and virulent challenge. Vet Rec 1988; 122: 573-576.
    CrossrefPubMedGoogle Scholar
  • 38 Mende K, Stuetzer B, Truyen U, Hartmann K. Evaluation of an in-house dot enzyme-linked immunosorbent assay to detect antibodies against feline panleukopenia virus. J Feline Med Surg 2014; 16: 805-811.
    CrossrefPubMedGoogle Scholar
  • 39 Mende K, Stuetzer B, Sauter-Louis C, Homeier T, Truyen U, Hartmann K. Prevalence of antibodies against feline panleukopenia virus in client-owned cats in Southern Germany. Vet J 2014; 199: 419-423.
    CrossrefPubMedGoogle Scholar
  • 40 Modrow S, Falke D, Truyen U, Schaetzl H. Molekulare Virologie. Heidelberg: Spektrum Akademischer Verlag 2010
    PubMedGoogle Scholar
  • 41 Mouzin DE, Lorenzen MJ, Haworth JD, King VL. Duration of serologic response to three viral antigens in cats. J Am Vet Med Assoc 2004; 224: 61-66.
    CrossrefPubMedGoogle Scholar
  • 42 Patterson EV, Reese MJ, Tucker SJ, Dubovi EJ, Crawford PC, Levy JK. Effect of vaccination on parvovirus antigen testing in kittens. J Am Vet Med Assoc 2007; 230: 359-363.
    CrossrefPubMedGoogle Scholar
  • 43 Pollock RVH, Postorino NC. Feline panleukopenia and other enteric viral diseases. In: The Cat: Diseases and Clinical Management. Sherding RG. ed. New York: Churchill Livingstone; 1994: 479-487.
    Google Scholar
  • 44 Poulet H. Alternative early life vaccination programs for companion animals. J Comp Pathol 2007; 137 (Suppl. 01) S67-71.
    CrossrefPubMedGoogle Scholar
  • 45 Reese MJ, Patterson EV, Tucker SJ, Dubovi EJ, Davis RD, Crawford PC, Levy JK. Effects of anesthesia and surgery on serologic responses to vaccination in kittens. J Am Vet Med Assoc 2008; 233: 116-121.
    CrossrefPubMedGoogle Scholar
  • 46 Scherk MA, Ford RB, Gaskell RM, Hartmann K, Hurley KF, Lappin MR, Levy JK, Little SE, Nordone SK, Sparkes AH. 2013 AAFP Feline Vaccination Advisory Panel Report. J Feline Med Surg 2013; 15: 785-808.
    CrossrefPubMedGoogle Scholar
  • 47 Scott FW, Csiza CK, Gillespie JH. Feline viruses. V. Serumneutralization test for feline panleukopenia. Cornell Vet 1970; 60: 183-191.
    PubMedGoogle Scholar
  • 48 Scott FW, Csiza CK, Gillespie JH. Maternally derived immunity to feline panleukopenia. J Am Vet Med Assoc 1970; 156: 439-453.
    PubMedGoogle Scholar
  • 49 Scott FW, Geissinger CM. Long-term immunity in cats vaccinated with an inactivated trivalent vaccine. Am J Vet Res 1999; 60: 652-658.
    PubMedGoogle Scholar
  • 50 Srivastav A, Kass PH, McGill LD, Farver TB, Kent MS. Comparative vaccine-specific and other injectable-specific risks of injection-site sarcomas in cats. J Am Vet Med Assoc 2012; 241: 595-602.
    CrossrefPubMedGoogle Scholar
  • 51 Tizard I, Ni Y. Use of serologic testing to assess immune status of companion animals. J Am Vet Med Assoc 1998; 213: 54-60.
    PubMedGoogle Scholar
  • 52 Tizard IR. ed. B cells and their response to antigen. In: Veterinary Immunology. Philadelphia: Saunders; 2012: 150-164.
    Google Scholar
  • 53 Tizard IR. ed. Helper T cells and their response to antigen. In: Veterinary Immunology. Philadelphia: Saunders; 2012: 137-149.
    Google Scholar
  • 54 Tizard IR. ed. Immunity in the fetus and newborn. In: Veterinary Immunology. Philadelphia: Saunders; 2012: 225-239.
    Google Scholar
  • 55 Tizard IR. ed. Vaccines and their production. In: Veterinary Immunology. Philadelphia: Saunders; 2012: 258-271.
    Google Scholar
  • 56 Truyen U, Addie D, Belak S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Thiry E, Horzinek MC. Feline panleukopenia. ABCD guidelines on prevention and management. J Feline Med Surg 2009; 01: 538-546.
    PubMedGoogle Scholar
  • 57 Waner T, Naveh A, Wudovsky I, Carmichael LE. Assessment of maternal antibody decay and response to canine parvovirus vaccination using a clinic-based enzyme-linked immunosorbent assay. J Vet Diagn Invest 1996; 08: 427-432.
    CrossrefPubMedGoogle Scholar
  • 58 Waner T, Mazar S, Keren-Kornblatt E. Application of a dot enzyme-linked immunosorbent assay for evaluation of the immune status to canine parvovirus and distemper virus in adult dogs before revaccination. J Vet Diagn Invest 2006; 18: 267-270.
    CrossrefPubMedGoogle Scholar