Subscribe to RSS
Download PDF
DOI: 10.15654/TPK-140217
Leptospirose mit hämorrhagisch-nekrotisierender Cholezystitis bei einem Boxerwelpen
Leptospirosis with necro-haemorrhagic cholecystitis in a Boxer puppyPublication History
Eingegangen:
04 March 2013
Akzeptiert nach Revision:
22 June 2014
Publication Date:
08 January 2018 (online)
Zusammenfassung
Ein von der Insel Rügen stammender altersgemäß geimpfter Boxerwelpe wurde mit akuter Magen-Darm-Symptomatik vorgestellt. Die Verdachtsdiagnose Leptospirose mit akutem Nierenversagen, Leberschädigung und Ikterus ließ sich durch Serokonversion (Titeranstieg auf 1:800 bei einer Nicht-Impfserogruppe 4 Wochen nach Krankheitsbeginn) bestätigen. Klinisch und sonographisch wurde eine Gallenblasenentzündung diagnostiziert. Nach anfänglicher Besserung kam es zu Rezidiven, sodass schließlich eine kurative Cholezystektomie durchgeführt wurde. Histopathologisch fand sich eine hämorrhagischnekrotisierende Cholezystitis.
Summary
A Boxer puppy from the island of Rügen, which was properly vaccinated according to its age, was presented with acute gastrointestinal symptoms. The presumptive diagnosis of leptospirosis with acute renal failure, hepatic damage, and jaundice was confirmed by seroconversion (increased titre to 1:800 in a non-vaccine serogroup 4 weeks after disease onset). Cholecystitis was diagnosed based on clinical symptoms and sonographic results. After an initial improvement, the puppy’s condition deteriorated and cholecystectomy was performed. Histopathological diagnosis indicated a haemorrhagic necrotizing cholecystitis.
-
Literatur
- 1 Baelen E, Roustan J. Leptospirosis associated with acute acalculous cholecystitis. Surgical or medical treatment? J Clin Gastroenterol 1997; 25 (04) 704-706.
- 2 Barton LL, Escobedo MB, Keating JP, Ternberg JL. Leptospirosis with acalculous Besso JG, Wrigley RH, Gliatto JM, Webster CR. Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder mucocele. Vet Radiol Ultrasound 2000; 41 (03) 261-271.
- 3 Besso JG, Wrigley RH, Gliatto JM, Webster CR. Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder mucocele. Vet Radiol Ultrasound 2000; 41 (03) 261-271.
- 4 Chong VH, Goh SK. Leptospirosis presenting as acute acalculous cholecystitis and pancreatitis. Ann Acad Med Singapore 2007; 36 (03) 215-216.
- 5 Croda J, Neto AN, Brasil RA, Pagliari C, Nicodemo AC, Duarte MI. Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface. 1. Clin Microbiol Infect 2010; 16 (06) 593-599.
- 6 Dalamaga M, Chavelas C, Kostoula A, Matekovits H, Karmaniolas K, Liatis S, Migdalis I. Leptospirosis presenting as acute pancreatitis and cholecystitis. J Med 2004; 35 (1–6): 181-185.
- 7 Gallagher A. Leptospirosis in a dog with uveitis and presumed cholecystitis. J Am Anim Hosp Assoc 2011; 47 (06) 162-167.
- 8 Geissen V, Stengel C, Hartmann K. Epidemiologische Situation der Leptospirose beim Hund in Süddeutschland. Tierärztl Prax 2008; 36 (K): 329-336.
- 9 Gerlach T, Stephan I. Epidemiologische Situation der kaninen Leptospirose in Norddeutschland in den Jahren 2003–2006 – eine retrospektive Studie. Tierärztl Prax 2007; 35 (K): 421-429.
- 10 Greene CE, Sykes JE, Brown CA, Hartmann K. Leptospirosis. In: Infectious Disease of the Dog and Cat. 3rd edn.. Greene CE. ed. St Louis, MO: Saunders Elsevier; 2006: 402-417.
- 11 Hakala T, Nuutinen PJ, Ruokonen ET, Alhava E. Microangiopathy in acute acalculous cholecystitis. Br J Surg 1997; 84 (09) 1249-1252.
- 12 Hicks CW, Sweeney DA, Danner RL, Eichacker PQ, Suffredini AF, Feng J, Sun J, Behrend EN, Solomon SB, Natanson C. Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock. Crit Care Med 2012; 40 (01) 199-207.
- 13 Holt DE, Mehler S, Mayhew PD, Hendrick MJ. Canine gallbladder infarction: 12 cases (1993–2003). Vet Pathol 2004; 41 (04) 416-418.
- 14 Klopfleisch R, Kohn B, Plog S, Weingart C, Nöckler K, Mayer-Scholl A, Gruber AD. An emerging pulmonary haemorrhagic syndrome in dogs: similar to the human leptospiral pulmonary haemorrhagic syndrome?. Vet Med Int. 2010 http://dx.doi.org/10.4061/2010/928541
- 15 Kohn B, Steinicke K, Arndt G, Gruber AD, Guerra B, Jansen A, Kaser-Hotz B, Klopfleisch R, Lotz F, Luge F, Nöckler K. Pulmonary abnormalities in dogs with leptospirosis. J Vet Intern Med 2010; 24 (06) 1277-1282.
- 16 Kohn B, Weingart C, Mayer-Scholl A, Nöckler K. Leptospirose beim Hund – aktuelle Aspekte zu Klinik, Diagnose, Therapie und Prophylaxe. Kleintierprax 2012; 57 (09) 461-474.
- 17 Levett PN. Leptospirosis. Clin Microbiol Rev 2001; 14 (02) 296-326.
- 18 Levett PN. Usefulness of serologic analysis as a predictor of the infecting serovar in patients with severe leptospirosis. Clin Infect Dis 2003; 36: 447-452.
- 19 Mayer-Scholl A, Luge E, Draeger A, Nöckler K, Kohn B. Distribution of Leptospira serogroups in dogs from Berlin, Germany. Vector Borne Zoonotic Dis 2013; 13 (03) 200-202.
- 20 Mehler SJ, Mayhew PD, Drobatz KJ, Holt DE. Variables associated with outcome in dogs undergoing extrahepatic biliary surgery: 60 cases (1988–2002). Vet Surg 2004; 33 (06) 644-649.
- 21 Monno S, Mizushima Y. Leptospirosis with acute acalculous cholecystitis and pancreatitis. J Clin Gastroenterol 1993; 16 (01) 52-54.
- 22 O’Neill EJ, Day MJ, Hall EJ, Holden DJ, Murphy KF, Barr FJ, Pearson GR. Bacterial cholangitis/cholangiohepatitis with or without concurrent cholecystitis in four dogs. J Small Anim Pract 2006; 47 (06) 325-335.
- 23 Peter G, Narasimha H. Acalculous cholecystitis: A rare presentation of leptospirosis progressing to Weil’s disease. Asian Pac J Trop Med 2011; 04: 1007-1008.
- 24 Rivers BJ, Walter PA, Johnston GR, Merkel LK, Hardy RM. Acalculous cholecystitis in four canine cases: ultrasonographic findings and use of ultrasonographic-guided, percutaneous cholecystocentesis in diagnosis. J Am Anim Hosp Assoc 1997; 33 (03) 207-214.
- 25 Smythe LD, Smith IL, Smith GA, Dohnt MF, Symonds ML, Barnett LJ, McKay DB. A quantitative PCR (TaqMan) assay for pathogenic Leptospira spp. BMC Infectious Diseases 2002; 02: 13.
- 26 Sykes JE, Hartmann K, Lunn KF, Moore GE, Stoddard RA, Goldstein RE. 2010 ACVIM Small Animal Consensus Statement on Leptospirosis: Diagnosis, Epidemiology, Treatment, and Prevention. J Vet Intern Med 2011; 25 (01) 1-13.
- 27 Tangeman LE, Littman MP. Clinicopathologic and atypical features of naturally occurring leptospirosis in dogs: 51 cases (2000–2010). J Am Vet Med Assoc 2013; 243 (09) 1316-1322.
- 28 Taoka H. Experimental study on the pathogenesis of acute acalculous cholecystitis, with special reference to the roles of microcirculatory disturbances, free radicals and membrane-bound phospholipase A2. Gastroenterol Jpn 1991; 26 (05) 633-644.
- 29 Townsend WM, Stiles J, Krohne SG. Leptospirosis and panuveitis in a dog. Vet Ophthalmol 2006; 09 (03) 169-173.
- 30 Vilaichone RK, Mahachai V, Wilde H. Acute acalculous cholecystitis in leptospirosis. J Clin Gastroenterol 1999; 29 (03) 280-283.
- 31 Vinetz JM. Leptospirosis. Curr Opin Infect Dis 2001; 14: 527-538.
- 32 Worley DR, Hottinger HA, Lawrence HJ. Surgical management of gallbladder mucoceles in dogs: 22 cases (1999–2003). J Am Vet Med Assoc 2004; 225 (09) 1418-1422.