Tierarztl Prax Ausg G Grosstiere Nutztiere 2018; 46(03): 150-153
DOI: 10.15653/TPG-170844
Originalartikel – Original Articles
Schattauer GmbH

Effect of denaverine hydrochloride application to heifers on the APGAR score and lactate concentration in newborn calves[*]

Effekt einer Denaverinhydrochlorid-Applikation bei Färsen auf APGAR-Score und Laktatkonzentration neugeborener Kälber
Katrin Lange
1   Clinic for Animal Reproduction, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany
,
Wolfgang Heuwieser
1   Clinic for Animal Reproduction, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany
,
Carola Fischer-Tenhagen
1   Clinic for Animal Reproduction, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany
› Author Affiliations
Further Information

Publication History

Received: 11 December 2017

Accepted after revision: 17 January 2018

Publication Date:
14 June 2018 (online)

Summary

Objective: The aim of this study was to evaluate the influence of Denaverine hydrochloride (DNH) in heifers on calf vitality. Material and methods: A total of 83 calvings with 38 female and 45 male calves were included in the study. Thirty minutes after onset of stage 2 of calving, 400 mg DNH or placebo (0.9% NaCl) were administered subcutaneously. If the calving procedure was not completed after 60 minutes, an extraction was conducted and pulling force was measured by using a digital force gauge. Directly after parturition, vitality of calves was evaluated using a modified APGAR score. Additionally, lactate concentration in blood from Vena auricularis was measured with a handheld measuring device (lactate scout). Results: No effect of treatment was observed on APGAR score and lactate concentration. Clinical relevance: Denaverine hydrochloride is a regularly used substance in obstetrics in veterinary medicine in many European countries. We could not confirm our hypotheses that treating heifers with DNH has a positive effect on calf vitality evaluated by APGAR score and lactate concentration in blood.

Zusammenfassung

Ziel: der Studie war, den Effekt einer Behandlung von Färsen mit Denaverinhydrochlorid auf die Vitalität der geborenen Kälber zu testen. Material und Methoden: Die Auswertung umfasste 83 Färsengeburten, bei denen 38 weibliche und 45 männliche Kälber geboren wurden. Eine halbe Stunde nach Beginn der Aufweitungsphase wurden dem Muttertier randomisiert 400 mg Denaverinhydrochlorid oder ein Plazebo subkutan appliziert. War das Kalb nach 60 Minuten nicht geboren, erfolgte eine Zughilfe mit Messung der benötigten Zugkraft. Unmittelbar nach der Geburt wurde die Vitalität des Kalbes mit einem modifizierten APGAR-Score bewertet und in einer Blutprobe aus der Vena auricularis mit einem Handmessgerät die Laktatkonzentration bestimmt. Ergebnisse Es wurde kein Effekt der Behand-lung auf APGAR-Score und Laktatkonzentration der Kälber im Blut festgestellt. Schlussfolgerung und klinische Relevanz: Denaverinhydrochlorid ist eine in vielen Ländern der EU in der Geburtshilfe regelmäßig eingesetzte Substanz. Wir konnten die Hypothese, dass die Behandlung von Färsen mit DNH einen positiven Effekt auf die Vitalität der Kälber hat, gemessen am APGAR-Score und der Laktatkonzentration im Blut, nicht beweisen.

* Dedicated to Professor Dr. Dr. h. c. mult. Hartwig Bostedt on the occasion of his 80th birthday.


 
  • References

  • 1 Andersen LW, Mackenhauer J, Roberts JC, Berg KM, Cocchi MN, Donnino MW. Etiology and therapeutic approach to elevated lactate levels. Mayo Clin Proc 2013; 88 (10) 1127-1140.
  • 2 Apgar V, Holaday DA, James LS, Weisbrot IM, Berrien C. Evaluation of the newborn infant; second report. JAMA 1958; 168: 1985-1988.
  • 3 Arieff AI, Graf H. Pathophysiology of type A hypoxic lactic acidosis in dogs. Am J Physiol 1987; 253: E271-276.
  • 4 Barrier AC, Ruelle E, Haskell MJ, Dwyer CM. Effect of a difficult calving on the vigour of the calf, the onset of maternal behaviour, and some beha-vioural indicators of pain in the dam. Prev Vet Med 2012; 103 (04) 248-256.
  • 5 Bleul U, Gotz E. The effect of lactic acidosis on the generation and compen-sation of mixed respiratory-metabolic acidosis in neonatal calves. Vet Rec 2013; 172: 528.
  • 6 Burfeind O, Heuwieser W. Validation of handheld meters to measure blood L-lactate concentration in dairy cows and calves. J Dairy Sci 2012; 95: 6449-6456.
  • 7 Consitt LA, Saxena G, Saneda A, Houmard JA. Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training. Am J Physiol En-docrinol Metab 2016; 311 (01) E145-56.
  • 8 Diesch TJ, Mellor DJ, Stafford KJ, Ward RN. The physiological and physical status of single calves at birth in a dairy herd in New Zealand. N Z Vet J 2004; 52: 250-255.
  • 9 Herfen K, Bostedt H. Correlation between clinical and laboratory diag-nostic evaluation of the vitality of newborn calves under particular consi-deration of length and type of parturition. Wien Tierarztl Monatsschr 1999; 86: 255-261.
  • 10 Homerosky ER, Caulkett NA, Timsit E, Pajor EA, Kastelic JP, Windeyer MC. Clinical indicators of blood gas disturbances, elevated L-lactate con-centration and other abnormal blood parameters in newborn beef calves. Vet J 2017; 219: 49-57.
  • 11 Hughes D, Rozanski ER, Shofer FS, Laster LL, Drobatz KJ. Effect of sam-pling site, repeated sampling, pH, and PCO2 on plasma lactate concentra-tion in healthy dogs. Am J Vet Res 1999; 60: 521-524.
  • 12 Hüller H, Scheler W. Zur Pharmakologie einer Serie neuer Benzilsäurederi-vate. Acta biologica et medica Germanica 1963; 11.
  • 13 Hüller H. Pharmakologie und Klinik von O-(2-Äthylbutoxy)-benzil-säure-2-dimethylaminoäthylesterhydrochlorid (= Spasmalgan). Zentralbl Pharm 1970; 109.
  • 14 Kasari TR. Physiologic mechanisms of adaptation in the fetal calf at birth. Vet Clin North Am Food Anim Pract 1994; 10 (01) 127-136.
  • 15 Lombard JE, Garry FB, Tomlinson SM, Garber LP. Impacts of dystocia on health and survival of dairy calves. J Dairy Sci 2007; 90 (04) 1751-1760.
  • 16 Meyer CL, Berger PJ, Koehler KJ, Thompson JR, Sattler CG. Phenotypic trends in incidence of stillbirth for Holsteins in the United States. J Dairy Sci 2001; 84: 515-523.
  • 17 Mülling M. Asphyxie des neugeborenen Kalbes. Prakt Tierarzt 1977; 58: 78-80.
  • 18 Murray CF, Leslie KE. Newborn calf vitality: Risk factors, characteristics, assessment, resulting outcomes and strategies for improvement. Vet J 2013; 198: 322-328.
  • 19 Schuijt G. Iatrogenic fractures of ribs and vertebrae during delivery in peri-natally dying calves: 235 cases (1978-1988). J Am Vet Med Assoc 1990; 197: 1196-202.
  • 20 Sorge U, Kelton D, Staufenbiel R. Neonatal blood lactate concentration and calf morbidity. Vet Rec 2009; 164: 533-534.
  • 21 Vermorel M, Dardillat C, Vernet J, Saido Demigne C. Energy metabolism and thermoregulation in the newborn calf. Ann Rech Vet 1983; 14: 382-389.
  • 22 Zobel R, Taponen J. Denaverine hydrochloride and carbetocin increased welfare during and after parturition and enhanced subsequent fertility in cattle. J Dairy Sci 2014; 97 (06) 3570-3577.