Klinische Studien zu neuen direkten oralen Antikoagulanzien

J. Harenberg; C. Weiss; S. Marx; S. Zolfaghari

doi:10.12687/phleb2146-3-2013

Phlebologie, Table of Contents

Phlebologie 2013; 42(03): 139-148
DOI: 10.12687/phleb2146-3-2013

Originalarbeit

Schattauer GmbH

Klinische Studien zu neuen direkten oralen Antikoagulanzien

Mehrwert indirekter Vergleiche (Netzwerkanalysen) Article in several languages: deutsch | English

J. Harenberg

¹Abteilung für klinische Pharmakologie, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland

,

C. Weiss

²Abteilung für Biometrie und Statistik, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland

,

S. Marx

¹Abteilung für klinische Pharmakologie, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland

,

S. Zolfaghari

¹Abteilung für klinische Pharmakologie, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland

› Author Affiliations

Abstract

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Zusammenfassung

Um die Wirksamkeit und Verträglichkeit neuer direkter oraler Antikoagulanzien (DOAK) zu vergleichen, müssten idealerweise eine direkte Gegenüberstellung der Substanzen in klinischen Studien durchgeführt werden. Auf Grund des logistischen und finanziellen Aufwandes wird dies aber in absehbarer Zeit nicht geschehen. Indirekte Vergleiche, auch Netzwerkanalysen (NMA) genannt, lassen sich mit den vorliegenden Studien zwischen den DOAKs vornehmen. In der postoperativen Phase nach Knie- und Hüftgelenkersatz und bei Patienten mit Vorhofflimmern sind derzeit diese Vergleich möglich. Indirekte Vergleiche sind jedoch auch mit Einschränkungen behaftet.

Diese Arbeit gibt eine Übersicht der aktuell vorliegenden NMAs und versucht, deren Ergebnisse mit der Pharmakologie der DOAKs und den methodischen Problemen von NMAs zu beleuchten.

Schlüsselwörter

Antikoagulanzien - Apixaban - Dabigatran - Rivaroxaban - Edoxaban - Vorhofflimmern - postoperative Thromboembolieprophylaxe

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References

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