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Thromb Haemost 2014; 112(05): 860-867
DOI: 10.1160/th14-03-0199
Theme Issue Article
Schattauer GmbH

The relevance of coagulation in cardiovascular disease: what do the biomarkers tell us?

Gordon Lowe
1   Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
,
Ann Rumley
1   Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
› Author Affiliations
Further Information

Publication History

Received: 11 March 2014

Accepted after major revision: 22 July 2014

Publication Date:
20 November 2017 (online)

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Summary

Several haemostatic factors have been associated with incident arterial cardiovascular disease in prospective studies and meta-analyses. Plasma fibrinogen shows a strong and consistent association with risk; however, this may reflect its inflammatory marker status, and causality remains to be proven. The common haemostatic gene polymorphisms for factor II, factor V and the von Willebrand factor: Factor VIII (non-O blood group) show significant associations with coronary heart disease (CHD) risk, consistent with potential causality. Increased D-dimer and t-PA antigen levels are associated with CHD risk, suggesting roles for coagulation activation and endothelial disturbance. There is little evidence for associations with CVD with other haemostatic factors.

Keywords

Arterial thrombosis - epidemiological studies - coagulation factors
 

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