Thromb Haemost 2017; 117(07): 1296-1316
DOI: 10.1160/TH16-12-0943
Position Paper
Schattauer GmbH

Microvesicles in vascular homeostasis and diseases

Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology
Victoria C. Ridger*
1  Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health and the INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, UK
,
Chantal M. Boulanger*
2  INSERM UMR-S 970, Paris Cardiovascular Research Center – PARCC, Paris, France
3  Université Paris Descartes, Sorbonne Paris Cité, Paris, France
,
Anne Angelillo-Scherrer
4  Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
5  Department of Clinical Research, University of Bern, Bern, Switzerland
,
Lina Badimon
6  Cardiovascular Research Center (CSIC-ICCC), IIB-Sant Pau, Barcelona, Spain
7  Cardiovascular Research Chair, UAB, Barcelona, Spain
,
Olivier Blanc-Brude
2  INSERM UMR-S 970, Paris Cardiovascular Research Center – PARCC, Paris, France
3  Université Paris Descartes, Sorbonne Paris Cité, Paris, France
,
Marie-Luce Bochaton-Piallat
8  Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
,
Eric Boilard
9  Centre de Recherche du CHU de Québec, Université Laval, Department of Infectious diseases and Immunity, Quebec City, Quebec, Canada
,
Edit I. Buzas
10  Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
,
Andreas Caporali
11  University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
,
Francoise Dignat-George
12  Aix-Marseille University, INSERM, VRCM, UMR-S1076, UFR de Pharmacie, Marseille, France
13  Department of Hematology and Vascular Biology, CHU La Conception, APHM, Marseille, France
,
Paul C. Evans
1  Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health and the INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, UK
,
Romaric Lacroix
12  Aix-Marseille University, INSERM, VRCM, UMR-S1076, UFR de Pharmacie, Marseille, France
13  Department of Hematology and Vascular Biology, CHU La Conception, APHM, Marseille, France
,
Esther Lutgens
14  Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
15  Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
,
Daniel F. J. Ketelhuth
16  Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
,
Rienk Nieuwland
17  Laboratory of Experimental Clinical Chemistry, Vesicle Observation Center, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
,
Florence Toti
18  Faculty of Pharmacy, UMR CNRS 7213, University of Strasbourg, Strasbourg, France
,
Jose Tuñon
19  IIS-Fundación Jiménez Díaz, Madrid, Spain
20  Autónoma University, Madrid, Spain
,
Christian Weber
15  Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
21  Cardiovascular Research Institute Maastricht (CARIM), 6229 ER Maastricht, The Netherlands
,
Imo E. Hoefer
22  Laboratory of Clinical Chemistry and Hematology, UMC Utrecht, Netherlands
› Author Affiliations
REVIEWERS:
Gregory Y. H. Lip review coordinator
23  Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK
,
Nikos Werner
24  Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany
,
Eduard Shantsila
23  Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK
,
Hugo ten Cate
25  UNS 50, University Medical Center, Maastricht, The Netherlands
,
Mark Thomas
23  Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK
,
Paul Harrison
26  Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
› Author Affiliations
Further Information

Publication History

Received: 19 December 2016

Accepted after major revision: 27 April 2017

Publication Date:
28 November 2017 (online)

Summary

Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as “microparticles”. There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.

* Equal contribution to this manuscript.