Thromb Haemost 2017; 117(02): 231-237
DOI: 10.1160/TH16-10-0770
Perspective
Schattauer GmbH

Atherosclerosis revisited from a clinical perspective: still an inflammatory disease?

Donato Santovito
1  Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Munich, Germany
,
Christian Weber
1  Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Munich, Germany
2  German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
› Author Affiliations
Financial support: The work of the authors is supported by the Deutsche Forschungsgemeinschaft (SFB1123, A1/B4).
Further Information

Publication History

Received:10 October 2016

Accepted after minor revision:10 November 2016

Publication Date:
13 November 2017 (online)

Summary

Compelling experimental results have substantiated the immune-driven inflammatory nature of atherosclerosis. Most of the scientific advances over the past decades have been achieved by relying on transgenic animal models that have been employed with increasing levels of sophistication. However, recent failures in translating various anti-inflammatory therapeutic strategies for use in humans might raise some skepticism with regards to an inflammatory causality underlying human atherosclerosis. By applying a dialectical approach, this Perspective aims to challenge and deduce the nature of atherosclerosis by reviewing results exclusively derived from human studies and recent clinical trials, as “things may not always be, what they appear”.

Note: The review process for this manuscript was fully handled by Gregory Y. H. Lip, Editor in Chief.