Thromb Haemost 2016; 116(04): 626-637
DOI: 10.1160/TH16-02-0091
Consensus Document
Schattauer GmbH

Role and analysis of monocyte subsets in cardiovascular disease

Joint consensus document of the European Society of Cardiology (ESC) Working Groups “Atherosclerosis & Vascular Biology” and “Thrombosis”
Christian Weber
1  Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany
2  German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
,
Eduard Shantsila
3  University of Birmingham, Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK
,
Michael Hristov
1  Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany
,
Giuseppina Caligiuri
4  INSERM, Bichat Hospital, Paris, France
,
Tomasz Guzik
5  Jagiellonian University, Krakow, Poland
6  University of Glasgow, Glasgow, UK
,
Gunnar H. Heine
7  Department of Internal Medicine IV, Saarland University Medical Center, Homburg, Germany
,
Imo E. Hoefer
8  Laboratory of Experimental Cardiology & Laboratory of Clinical Chemistry and Hematology, UMC Utrecht, Netherlands
,
Claudia Monaco
9  University of Oxford, Oxford, UK
,
Karlheinz Peter
10  Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
,
Ed Rainger
3  University of Birmingham, Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK
,
Agneta Siegbahn
11  Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
,
Sabine Steffens
1  Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany
2  German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
,
Johann Wojta
12  Department of Internal Medicine II, Core Facilities, Medical University of Vienna, Vienna, Austria
,
Gregory Y. H. Lip
3  University of Birmingham, Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK
› Author Affiliations
Further Information

Publication History

Received: 04 February 2016

Accepted after major revision: 02 June 2016

Publication Date:
02 December 2017 (online)

Summary

Monocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.

Note: The review process for this paper was fully handled by Lina Badimon, Section Editor.