Role and analysis of monocyte subsets in cardiovascular disease

Christian Weber; Eduard Shantsila; Michael Hristov; Giuseppina Caligiuri; Tomasz Guzik; Gunnar H. Heine; Imo E. Hoefer; Claudia Monaco; Karlheinz Peter; Ed Rainger; Agneta Siegbahn; Sabine Steffens; Johann Wojta; Gregory Y. H. Lip

doi:10.1160/TH16-02-0091

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2016; 116(04): 626-637
DOI: 10.1160/TH16-02-0091

Consensus Document

Schattauer GmbH

Role and analysis of monocyte subsets in cardiovascular disease

Joint consensus document of the European Society of Cardiology (ESC) Working Groups “Atherosclerosis & Vascular Biology” and “Thrombosis”

Authors

Christian Weber

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany

²German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
Eduard Shantsila

³ University of Birmingham, Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK
Michael Hristov

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany
Giuseppina Caligiuri

⁴INSERM, Bichat Hospital, Paris, France
Tomasz Guzik

⁵Jagiellonian University, Krakow, Poland

⁶University of Glasgow, Glasgow, UK
Gunnar H. Heine

⁷Department of Internal Medicine IV, Saarland University Medical Center, Homburg, Germany
Imo E. Hoefer

⁸Laboratory of Experimental Cardiology & Laboratory of Clinical Chemistry and Hematology, UMC Utrecht, Netherlands
Claudia Monaco

⁹University of Oxford, Oxford, UK
Karlheinz Peter

¹⁰Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Ed Rainger

³ University of Birmingham, Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK
Agneta Siegbahn

¹¹Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
Sabine Steffens

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany

²German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
Johann Wojta

¹²Department of Internal Medicine II, Core Facilities, Medical University of Vienna, Vienna, Austria
Gregory Y. H. Lip

³ University of Birmingham, Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK

Abstract

Summary

Monocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.

Note: The review process for this paper was fully handled by Lina Badimon, Section Editor.

Keywords

Atherosclerosis - leukocyte function / activation - monocytes

Volltext

Referenzen

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