Normalised immune expression in remission of paediatric ITP

• References

• 1 Harrington WJ. et al. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 1951; 38: 1-10.
• 2 Olsson B. et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 2003; 9: 1123-1124.
• 3 Cines DB, Schreiber AD. Immune thrombocytopenia. Use of a Coombs antiglobulin test to detect IgG and C3 on platelets. N Engl J Med 1979; 300: 106-111.
• 4 Rodeghiero F. et al. Standardisation of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 2009; 113: 2386-2393.
• 5 Neunert CE. et al. Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group (ICIS). Blood 2013; 121: 4457-4462.
• 6 Jernas M. et al. MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP). Blood 2013; 121: 2095-2098.
• 7 Spolski R, Leonard WJ. Interleukin-21: a doubleedged sword with therapeutic potential. Nat Rev Drug Discov 2014; 13: 379-395.
• 8 Jones JL. et al. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest 2009; 119: 2052-2061.
• 9 Zhu X. et al. Elevated interleukin-21 correlated to Th17 and Th1 cells in patients with immune thrombocytopenia. J Clin Immunol 2010; 30: 253-259.
• 10 Kisand K. et al. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J Exp Med 2010; 207: 299-308.
• 11 Gaffen SL. et al. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol 2014; 14: 585-600.
• 12 Rocha AM. et al. The levels of IL-17A and of the cytokines involved in Th17 cell commitment are increased in patients with chronic immune thrombocytopenia. Haematologica 2011; 96: 1560-1564.
• 13 Wang JD. et al. Reduced expression of transforming growth factor-beta1 and correlated elevation of interleukin-17 and interferon-gamma in paediatric patients with chronic primary immune thrombocytopenia (ITP). Paediatr Blood Cancer 2011; 57: 636-640.
• 14 Belnoue E. et al. APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells. Blood 2008; 111: 2755-2764.