Thromb Haemost 2015; 114(01): 4
DOI: 10.1160/TH15-06-0447
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Schattauer GmbH

Fibronectin extradomain A: balancing atherosclerotic plaque burden and stability

Donato Santovito
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich and DZHK (German Centre for Cardiovascular Prevention), partner site Munich Heart Alliance, Munich, Germany
,
Christian Weber
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich and DZHK (German Centre for Cardiovascular Prevention), partner site Munich Heart Alliance, Munich, Germany
› Author Affiliations
Further Information

Publication History

Received: 02 June 2015

Accepted: 02 June 2015

Publication Date:
22 November 2017 (online)

Insight on Pulakazhi Venu et al. Thromb Haemost 2015; 114: 186–197.

 
  • References

  • 1 Rohwedder I, Montanez E, Beckmann K. et al. Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med 2012; 04: 564-576.
  • 2 Babaev VR, Porro F, Linton MF. et al. Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice. Atherosclerosis 2008; 197: 534-540.
  • 3 Pulakazhi Venu VK, Uboldi P, Dhyani A. et al. Fibronectin extra domain A stabilises atherosclerotic plaques in apolipoprotein E and in LDL-receptor-deficient mice. Thromb Haemost 2015; 114: 186-197.
  • 4 van Keulen JK, de Kleijn DP, Nijhuis MMO. et al. Levels of extra domain A containing fibronectin in human atherosclerotic plaques are associated with a stable plaque phenotype. Atherosclerosis 2007; 195: e83-91.
  • 5 Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011; 17: 1410-1422.