Download PDF
Thromb Haemost 2015; 113(05): 952-957
DOI: 10.1160/TH14-10-0858
Coagulation and Fibrinolysis
Schattauer GmbH

Association between pneumoconiosis and pulmonary emboli

A Nationwide Population-Based Study in Taiwan
Chih-Hao Shen
1   Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
,
Hsuan-Ju Chen
2   Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
3   College of Medicine, China Medical University, Taichung, Taiwan
,
Te-Yu Lin
4   Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
,
Wen-Yen Huang
5   Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
,
Tsai-Chung Li
6   Graduate Institute of Biostatistics, College of Management, China Medical University, Taichung, Taiwan
7   Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan
,
Chia-Hung Kao
8   Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan
9   Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
› Author Affiliations
Further Information

Publication History

Received: 14 October 2014

Accepted after minor revision: 21 January 2014

Publication Date:
24 November 2017 (online)

    Permissions and Reprints

Summary

Studies on the association between pneumoconiosis and deep-vein thrombosis (DVT) and pulmonary thromboembolism (PE) are few. This study was based on data obtained from the Taiwan National Health Insurance Database from 2000 to 2006, with a follow-up period extending to the end of 2011. We identified 3719 pneumoconiosis patients and 14876 non-pneumoconiosis patients who were selected by frequency matched based on sex, age, and the index year. We analysed the risks of DVT and PE by using Cox proportional hazards regression models by including sex, age, and CCI score. The risk of developing PE was 1.90-fold in the patients with pneumoconiosis compared with the comparison cohort after adjustments for age, sex, and CCI score. By contrast, we did not observe significant effect of pneumoconiosis on DVT. However, the cumulative incidence curves for DVT were similar in the pneumoconiosis patients and non-pneumoconiosis patients. The multiplicative increased risks of PE were significant in patients with pneumoconiosis and CCI score of one and more. In conclusion, physicians should include pneumoconiosis in evaluating pulmonary embolism risk.

Keywords

National Health Insurance Database - pneumoconiosis - pulmonary embolism - venous thrombosis
 

  • References

  • 1 Fourth International Pneumoconiosis Conference. Report of the Working Party on the Definition of Pneumoconiosis. Geneva, Switzerland: International Labour Organization 1971
    Google Scholar
  • 2 Fujimura N. Pathology and pathophysiology of pneumoconiosis. Curr Opin Pulm Med 2000; 06: 140-144.
    CrossrefPubMedGoogle Scholar
  • 3 Castranova V, Vallyathan V. Silicosis and coal workers’ pneumoconiosis. Environ Health Perspect 2000; 108: 675-684.
    CrossrefPubMedGoogle Scholar
  • 4 Cohen RA, Patel A, Green FH. Lung disease caused by exposure to coal mine and silica dust. Semin Respir Crit Care Med 2008; 29: 651-661.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Yucesoy B, Vallyathan V, Landsittel DP. et al. Cytokine polymorphisms in silicosis and other pneumoconioses. Mol Cell Biochem 2002; 234-235: 219-224.
    CrossrefPubMedGoogle Scholar
  • 6 Heit JA. Venous thromboembolism: disease burden, outcomes and risk factors. J ThrombHaemost 2005; 03: 1611-1617.
    CrossrefPubMedGoogle Scholar
  • 7 Goldhaber SZ, Bounameaux H. Pulmonary embolism and deep vein thrombosis. Lancet 2012; 379: 1835-1846.
    CrossrefPubMedGoogle Scholar
  • 8 Virchow R. Gesammelte Abhandlungen zur wissenschaftlichen Medicin. Frankfurt: Verlag von MeidlingerSohn 1856
    Google Scholar
  • 9 Kyrle PA, Eichinger S. Deep vein thrombosis. Lancet 2005; 365: 1163-1174.
    CrossrefPubMedGoogle Scholar
  • 10 Fox EA, Kahn SR. The relationship between inflammation and venous thrombosis. A systematic review of clinical studies. Thromb Haemost 2005; 94: 362-365.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Xu J, Lupu F, Esmon CT. Inflammation, innate immunity and blood coagulation. Hamostaseologie 2010; 30: 5-6-8-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Zhang C. The role of inflammatory cytokines in endothelial dysfunction. Basic Res Cardiol 2008; 103: 398-406.
    CrossrefPubMedGoogle Scholar
  • 13 Zöller B, Li X, Sundquist J. et al. Autoimmune diseases and venous thromboembolism: a review of the literature. Am J Cardiovasc Dis 2012; 02: 171-183.
    PubMedGoogle Scholar
  • 14 Schneider C, Bothner U, Jick SS. et al. Chronic obstructive pulmonary disease and the risk of cardiovascular diseases. Eur J Epidemiol 2010; 25: 253-260.
    CrossrefPubMedGoogle Scholar
  • 15 Bertoletti L, Quenet S, Mismetti P. et al. RIETE Investigators. Clinical presentation and outcome of venous thromboembolism in COPD. Eur Respir J 2012; 39: 862-868.
    CrossrefPubMedGoogle Scholar
  • 16 Charlson ME, Pompei P, Ales KL. et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-383.
    CrossrefPubMedGoogle Scholar
  • 17 White RH. The epidemiology of venous thromboembolism. Circulation 2003; 107: I4-I8.
    PubMedGoogle Scholar
  • 18 Diebold J, Lohrs U. Venous thrombosis and pulmonary embolism. A study of 5039 autopsies. Pathol Res Pract 1991; 187: 260-266.
    CrossrefPubMedGoogle Scholar
  • 19 Velmahos GC, Spaniolas K, Tabbara M. et al. Pulmonary embolism and deep venous thrombosis in trauma: are they related?. Arch Surg 2009; 144: 928-932.
    CrossrefPubMedGoogle Scholar
  • 20 Schwartz T, Hingorani A, Ascher E. et al. Pulmonary embolism without deep venous thrombosis. Ann Vasc Surg 2012; 26: 973-976.
    CrossrefPubMedGoogle Scholar
  • 21 Van Gent JM, Zander AL, Olson EJ. et al. Pulmonary embolism without deep venous thrombosis: De novo or missed deep venous thrombosis?. J Trauma Acute Care Surg 2014; 76: 1270-1274.
    CrossrefPubMedGoogle Scholar
  • 22 Kuppalli K, Livorsi D, Talati NJ. et al. Lemierre’s syndrome due to Fusobacteriumnecrophorum. Lancet Infect Dis 2012; 12: 808-815.
    CrossrefPubMedGoogle Scholar
  • 23 Hu SN, Vallyathan V, Green FH. et al. Pulmonary arteriolar muscularization in coal workers’ pneumoconiosis and its correlation with right ventricular hypertrophy. Arch Pathol Lab Med 1990; 114: 1063-1070.
    PubMedGoogle Scholar
  • 24 Murray J, Reid G, Kielkowski D. et al. Corpulmonale and silicosis: a necropsy based case-control study. Br J Ind Med 1993; 50: 544-548.
    PubMedGoogle Scholar
  • 25 Lopez JA, Chen J. Pathophysiology of venous thrombosis. Thromb Res 2009; 123: S30-S34.
    PubMedGoogle Scholar
  • 26 Hamer JD, Malone PC, Silver IA. The PO2 in venous valve pockets: its possible bearing on thrombogenesis. Br J Surg 1981; 68: 166-170.
    CrossrefPubMedGoogle Scholar
  • 27 Levi M, van der Poll T, ten Cate H. Tissue factor in infection and severe inflammation. Semin Thromb Hemost 2006; 32: 33-39.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 28 Montagnana M, Favaloro EJ, Franchini M, Guidi GC, Lippi G. The role of ethnicity, age and gender in venous thromboembolism. J Thromb Thrombolysis 2010; 29: 489-496.
    CrossrefPubMedGoogle Scholar
  • 29 Franchini M, Mannucci PM. ABO blood group and thrombotic vascular disease. Thromb Haemost 2014; 112: 1103-1109.
    Article in Thieme ConnectPubMedGoogle Scholar