Delayed-onset heparin-induced thrombocytopenia without thrombosis in a patient receiving postoperative thromboprophylaxis with rivaroxaban

• References

• 1 Warkentin TE, Basciano PA, Knopman J. et al. Spontaneous heparin induced thrombocytopenia syndrome: 2 new cases and proposal for defining this disorder. Blood 2014; 123: 3651-3654.
• 2 Warkentin TE, Kelton JG. Delayed-onset heparin-induced thrombocytopenia and thrombosis. Ann Intern Med 2001; 35: 502-506.
• 3 Rice L, Attisha WK, Drexler A, Francis JL. Delayed-onset heparin-induced thrombocytopenia. Ann Intern Med 2002; 136: 210-215.
• 4 Sheridan D, Carter C, Kelton JG. A diagnostic test for heparin induced thrombocytopenia. Blood 1986; 67: 27-30.
• 5 Sistino JJ, Owitz D, Mongero LB. Heparin washout in the pediatric Cell Saver bowl. J Extra Corpor Technol 1992; 24: 94-96.
• 6 Kling D, Börner U, von Bormann B. et al. Heparin elimination and free hemoglobin following cell separation and washing of autologous blood with cell Saver. Anasth Intensivther Notfallmed 1988; 23: 88-90.
• 7 Tardy-Poncet B, Piot M, Chapelle C. et al. Thrombin generation and heparin induced thrombocytopenia. J Thromb Haemost 2009; 07: 1474-1481.
• 8 Mueck W, Stampfuss J, Kubitza D. et al. Clinical pharmacokinetic and pharmacodynamic profile of rivaroxaban. Clin Pharmacokinet 2014; 53: 1-16.
• 9 Krauel K, Hachbarth C, Greinacher A. Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban and lowsulfated heparin with platelet factor 4 and anti-PF4/heparin antibodies. Blood 2012; 119: 1248-1255.
• 10 Farner B, Eichler P, Kroll H. et al. A comparison of danaparoid and lepirudin in heparin induced thrombocytopenia. Thromb Haemost 2001; 85: 950-957.
• 11 Warkentin TE, Safyan EL, Linkins LA. Heparin-induced thrombocytopenia presenting as bilateral hemorrhages. N Engl J Med 2015; 372: 492-494.
• 12 Greinacher A. Me or not me? The danger of spontaneity. Blood 2014; 123: 3536-3538.