CX₃CL1, a special deputy at the intersection of platelets and the vessel wall

 

Editorial Focus on: Hildemann et al. Thromb Haemost 2014; 111: 725-735.

• References

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• 2 Stolla M, Pelisek J, von Brühl M-L. et al. Fractalkine is expressed in early and advanced athero-sclerotic lesions and supports monocyte recruitment via CX3CR1.. PLoS ONE 2012; 7: e43572.
• 3 Landsman L, Ber-On L, Zernecke A. et al. CX3CR1-mediated cell survival in monocyte homeostasis and atherogenesis.. Blood 2009; 113: 963-972.
• 4 Richter B, Koller L, Hohensinner PJ. et al. Fractalkine is an independent predictor of mortality in patients with advanced heart failure.. Thromb Hae-most 2012; 108: 1220-1227.
• 5 McDermott DH, Fong AM, Yang Q. et al. Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans.. J Clin Invest 2003; 111: 1241-1250.
• 6 Postea O, Vasina EM, Cauwenberghs S. et al. Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia.. Arterioscler Thromb Vasc Biol 2012; 32: 1186-1193.
• 7 Hildemann SK, Schulz C, Fraccarollo D. et al. Fractalkine promotes platelet activation and vascular dysfunction in congestive heart failure.. Thromb Haemost 2014; 111: 725-735.