Thromb Haemost 2014; 111(06): 1191-1193
DOI: 10.1160/TH13-12-1012
Letters to the Editor
Schattauer GmbH

Atherosclerosis is not a risk factor for antiplatelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery

Adam Cuker
1   Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
2   Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Lubica Rauova
3   Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
4   Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
,
Douglas Bolgiano
5   Puget Sound Blood Center, Seattle, Washington, USA
,
William H. Matthai Jr.
1   Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Mortimer Poncz
3   Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
4   Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
,
Barbara A. Konkle
5   Puget Sound Blood Center, Seattle, Washington, USA
6   University of Washington School of Medicine, Seattle, Washington, USA
› Author Affiliations
Financial support: This work was supported by grants HL112903 and HL099973.
Further Information

Publication History

Received: 11 December 2013

Accepted after minor revision: 09 January 2014

Publication Date:
02 December 2017 (online)

 

 
  • References

  • 1 Amiral J, Bridey F, Dreyfus M. et al. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 1992; 68: 95-96.
  • 2 Pouplard C, May MA, Regina S. et al. Changes in platelet count after cardiac surgery can effectively predict the development of pathogenic heparindependent antibodies. Br J Haematol 2005; 128: 837-841.
  • 3 Gluckman TJ, Segal JB, Schulman SP. et al. Effect of anti-platelet factor-4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgery. J Thromb Haemost 2009; 07: 1457-1464.
  • 4 Selleng S, Malowsky B, Strobel U. et al. Early-onset and persisting thrombocytopenia in postcardiac surgery patients is rarely due to heparin-induced thrombocytopenia, even when antibody tests are positive. J Thromb Haemost 2010; 08: 30-36.
  • 5 Kuitunen A, Suojaranta-Ylinen R, Raivio P. et al. Heparin-induced thrombocytopenia following cardiac surgery is associated with poor outcome. J Cardiothorac Vasc Anesth 2007; 21: 18-22.
  • 6 Bauer TL, Arepally G, Konkle BA. et al. Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation 1997; 95: 1242-1246.
  • 7 Everett BM, Yeh R, Foo SY. et al. Prevalence of heparin/platelet factor 4 antibodies before and after cardiac surgery. Ann Thorac Surg 2007; 83: 592-597.
  • 8 Warkentin TE, Sheppard JA, Moore JC. et al. Studies of the immune response in heparin-induced thrombocytopenia. Blood 2009; 113: 4963-4969.
  • 9 Krauel K, Weber C, Brandt S. et al. Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes. Blood 2012; 120: 3342-3352.
  • 10 Pitsilos S, Hunt J, Mohler ER. et al. Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Thromb Haemost 2003; 90: 1112-1120.
  • 11 Mullen MP, Wessel DL, Thomas KC. et al. The incidence and implications of anti-heparin platelet factor 4 antibody formation in a pediatric cardiac surgical population. Anesth Analg 2008; 107: 371-378.