The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer

Zsolt Baranyai; Marcin Krzystanek; Valéria Jósa; Kristóf Dede; Emese Ágoston; Marcell Szász; Dániel Sinkó; Viktor Szarvas; Ferenc Salamon; Aron Charles Eklund; Zoltán Szállási; Ferenc Jakab

doi:10.1160/TH13-08-0632

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2014; 111(03): 483-490
DOI: 10.1160/TH13-08-0632

Platelets and Blood Cells

Schattauer GmbH

The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer

Zsolt Baranyai^*

¹Tumorgenetika Human Biospecimen Collection and Research Company, Budapest, Hungary

²1st Department of Surgery, Semmelweis University, Budapest, Hungary

,

Marcin Krzystanek^*

³Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

,

Valéria Jósa

¹Tumorgenetika Human Biospecimen Collection and Research Company, Budapest, Hungary

,

Kristóf Dede

⁴Department of Surgery and Vascular Surgery, Uzsoki Memorial Hospital, Budapest, Hungary

,

Emese Ágoston

²1st Department of Surgery, Semmelweis University, Budapest, Hungary

,

Marcell Szász

⁵2nd Department of Pathology, Semmelweis University, Budapest, Hungary

,

Dániel Sinkó

⁶Department of Oncology, Uzsoki Memorial Hospital, Budapest, Hungary

,

Viktor Szarvas

⁶Department of Oncology, Uzsoki Memorial Hospital, Budapest, Hungary

,

Ferenc Salamon

⁷Department of Pathology, Uzsoki Memorial Hospital, Budapest, Hungary

,

Aron Charles Eklund

³Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

,

Zoltán Szállási

³Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

⁸Informatics Program, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA

,

Ferenc Jakab

⁴Department of Surgery and Vascular Surgery, Uzsoki Memorial Hospital, Budapest, Hungary

› Author Affiliations

Abstract

Summary

The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years were collected retrospectively from 336 patients with CRC and 118 patients with mCRC. Both in the CRC and the mCRC group overall survival (OS) was significantly worse in patients who had elevated platelet count (hazard ratio [HR] = 2.2, p < 0.001 and HR = 2.9, p = 0.018, respectively). Multivariate analysis indicated that elevated platelet count was an independent prognostic factor of CRC (HR = 1.7, p = 0.035) and mCRC (HR = 3.1, p = 0.017). Disease-free survival (DFS) was significantly worse in patients with elevated platelet count in the CRC group (HR = 2.0, p = 0.011). In the multivariate analysis the PLR was not a prognostic factor in either of the two cohorts (HR = 0.92, p < 0.001 and HR = 0.89, p = 0.789, respectively). The platelet count is a valuable prognostic marker for the survival in patients both with CRC and mCRC while the PLR is not prognostic in either group.

Keywords

Platelet-lymphocyte ratio - thrombocytosis - colorectal cancer - survival

Full Text

References

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