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Thromb Haemost 2014; 111(04): 748-760
DOI: 10.1160/TH13-07-0593
Cardiovascular Biology and Cell Signalling
Schattauer GmbH

Tissue factor/factor VIIa induces cell survival and gene transcription by transactivation of the insulin-like growth factor 1 receptor

Mikael Åberg
1   Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
,
Oskar Eriksson
1   Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
,
Dariush Mokhtari
1   Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
,
Agneta Siegbahn
1   Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
› Author Affiliations Financial support: This study was supported by grants from the Swedish Research Council, the Swedish Heart and Lung Foundation, and the Gustaf V and Queen Victoria Foundation. D.M. is supported by the Göran Gustafsson Foundation.
Further Information

Publication History

Received: 21 July 2013

Accepted after major revision: 19 November 2013

Publication Date:
29 November 2017 (online)

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Summary

The insulin-like growth factor 1 receptor (IGF-1R) is known to promote survival and has also been implicated in the pathogenesis of several disease states, including cardiovascular disorders and cancer. Recently, we showed that binding of coagulation factor VIIa (FVIIa) to its receptor tissue factor (TF) protects cancer cells from TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis. Here we present evidence that this biological function of TF/FVIIa is dependent on the IGF-1R. IGF-1R inhibitors AG1024 and PPP as well as siRNA-mediated downregulation of IGF-1R, abolished the TF/FVIIa-mediated protection against TRAIL-induced apoptosis. Moreover, FVIIa rapidly induced a time- and concentration-dependent tyrosine phosphorylation of the IGF-1R in MDA-MB-231 breast cancer cells and in primary human monocytes, an event that was accompanied by IGF-1R chromatin binding and gene transcription. We hereby present novel evidence of a cross-talk between the coagulation and IGF-1R signalling systems, and propose that the IGF-1R is a key player in mediating TF/FVIIa-induced cell survival.

Keywords

Tissue factor - FVIIa - Apoptosis - IGF-1R - Cell signalling

 

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