Anti-inflammatory, anti-coagulant, anti-biotic?

 

T&H Insight on ► Franks et al. Thromb Haemost 2013; 109: 684-695.

• References

• 1 Schouten M, van 't Veer C, Roelofs JJ. et al. Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia. Thromb Haemost 2011; 106: 1189-1196.
• 2 In brief: Xigris withdrawn. Med Lett Drugs Ther 2011; 53: 104.
• 3 Franks Z, Campbell RA, Vieira de Abreu A. et al. Methicillin-resistant Staphylococcus aureus - induced thromboinflammatory response is reduced with timely antibiotic administration. Thromb Haemost 2013; 109: 684-695.
• 4 Kumar A, Roberts D, Wood KE. et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34: 1589-1596.