Factor IX activity/antigen ratio and the risk of first unprovoked venous thromboembolism

• References

• 1 Van Hylckama Vlieg, van der Linden I, Bertina RM. et al. High levels of factor IX increase the risk of venous thrombosis. Blood 2000; 95: 3678-3682.
• 2 Simioni P, Tormene D, Tognin G. et al. X-Linked Thrombophilia with a Mutant Factor IX (Factor IX Padua). N Engl J Med 2009; 361: 1671-1675.
• 3 Prandoni P, Noventa F, Ghirarduzzi A. et al. The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients. Haematologica 2007; 92: 199-205.
• 4 van Minkelen R, de Visser MC, van Hylckama Vlieg A. et al. Sequence variants and haplotypes of the factor IX gene and the risk of venous thrombosis. J Thromb Haemost 2008; 06: 1610-1613.
• 5 Bezemer ID, Arellano AR, Tong CH. et al. F9 Malmö, factor IX and deep vein thrombosis. Haematologica 2009; 94: 693-699.
• 6 Koenderman JS, Bertina RM, Reitsma PH. et al. Factor IX-R338L (Factor IX Padua) screening in a Dutch population of sibpairs with early onset venous thromboembolism. Thromb Res 2011; 128: 603.
• 7 Mazetto BM, Orsi FL, Siqueira LH. et al. Prevalence of Factor IX-R338L (Factor IX Padua) in a cohort of patients with venous thromboembolism and mild elevation of factor IX levels. Thromb Res 2010; 126: e165.