Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2011; 105(06): 1124DOI: 10.1160/TH11-02-0120 Letters to the Editor Schattauer GmbH Reasons for aspirin resistance Andrzej Szczeklik 1 Jagiellonian University Medical College, Department of Medicine, Kraków, Poland › Author AffiliationsRecommend Article Abstract Buy Article Full Text References References 1 Szczeklik A, Musial J, Undas A. et al. Aspirin resistance. J Thromb Haemost 2005; 3: 1655-1662. 2 Henry P, Vermillet A, Boval B. et al. 24-hour time-dependent aspirin efficacy in patients with stable coronary artery disease. Thromb Haemost 2011; 105: 336-344. 3 Lordkipanidze M. Why an aspirin a day no longer keeps the doctor away …. Thromb Haemost 2011; 105: 209-210. 4 Szczeklik A, Musial J, Undas A. et al. Inhibition of thrombin generation by aspirin is blunted in hyper-cholesterolemia. Arterioscler Thromb Vasc Biol 1996; 16: 948-954. 5 Undas A, Brummel KE, Musial J. et al. Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation. Circulation 2001; 103: 2248-2253. 6 Szczeklik A, Dropinski J, Radwan J. et al. Persistent generation of thrombin after acute myocardial infarction. Arterioscler Thromb Vasc Biol 1992; 12: 548-553. 7 Merlini PA, Bauer KA, Oltrona L. et al. Persistent activation of coagulation mechanism in unstable an-gina and myocardial infarction. Circulation 1994; 90: 61-68. 8 Grove EL, Hvas AM, Johnsen HL. et al. A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease. Thromb Haemost 2010; 103: 1245-1253. 9 Goodman T, Ferro A, Sharma P. Pharmacogenetics of aspirin resistance: a comprehensive systematic review. Br J Clin Pharmacol 2008; 66: 222-232. 10 Nurden AT. Platelet glycoprotein IIIa polymorphism and coronary thrombosis. Lancet. 1997; 350: 1189-1191. 11 Undas A, Sanak M, Musial J. et al. Platelet glycoprotein IIIa polymorphism, aspirin, and thrombin generation. Lancet 1999; 353: 982-983. 12 Szczeklik A, Undas A, Sanak M. et al. Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa. Br J Haematol 2000; 110: 965-967.