PDF herunterladen
Thromb Haemost 2011; 106(02): 272-278
DOI: 10.1160/TH11-01-0043
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Alcohol consumption, types of alcoholic beverages and risk of venous thromboembolism – The Tromsø Study

Ida J. Hansen-Krone
1   Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
,
Sigrid K. Brækkan
1   Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
2   Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
,
Kristin F. Enga
1   Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
,
Tom Wilsgaard
3   Department of Community Medicine, University of Tromsø, Tromsø, Norway
,
John-Bjarne Hansen
1   Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
2   Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 28. Januar 2011

Accepted after major revision: 03. Mai 2011

Publikationsdatum:
25. November 2017 (online)

    Lizenzen und Reprints

Summary

Moderate alcohol consumption has been shown to protect against cardiovascular diseases. The association between alcohol consumption, especially types of alcoholic beverages, and venous thromboembolism (VTE) is less well described. The aim of this study was to investigate the impact of alcohol consumption and different alcoholic beverages on risk of VTE. Information on alcohol consumption was collected by a selfadministrated questionnaire in 26,662 subjects, aged 25–97 years, who participated in the Tromsø Study, in 1994–1995. Subjects were followed through September 1, 2007 with incident VTE as the primary outcome. There were 460 incident VTE-events during a median of 12.5 years of follow-up. Total alcohol consumption was not associated with risk of incident VTE. However, subjects consuming ≥3 units of liquor per week had 53% increased risk of VTE compared to teetotalers in analyses adjusted for age, sex, body mass index, smoking, diabetes, cancer, previous cardiovascular disease, physical activity and higher education (HR: 1.53, 95% CI: 1.00–2.33). Contrary, subjects with a wine intake of ≥3 units/week had 22% reduced risk of VTE (HR: 0.78, 95% CI: 0.47–1.30), further adjustment for liquor and beer intake strengthened the protective effect of wine (HR: 0.53, 95% CI: 0.30–1.00). Frequent binge drinkers (≥1/week) had a 17% increased risk of VTE compared to teetotallers (HR 1.17, 95% CI: 0.66–2.09), and a 47% increased risk compared to non-binge drinkers (HR 1.47, 95% CI: 0.85–2.54). In conclusion, liquor consumption and binge drinking was associated with increased risk of VTE, whereas wine consumption was possibly associated with reduced risk of VTE.

Keywords

Alcohol - prospective cohort - risk factors - venous thromboembolism
 

  • References

  • 1 Heit JA. Venous thromboembolism: disease burden, outcomes and risk factors. J Thromb Haemost 2005; 3: 1611-1617.
    CrossrefPubMedGoogle Scholar
  • 2 Kahn SR, Shbaklo H, Lamping DL. et al. Determinants of health-related quality of life during the 2 years following deep vein thrombosis. J Thromb Haemost 2008; 6: 1105-1112.
    CrossrefPubMedGoogle Scholar
  • 3 Silverstein MD, Heit JA, Mohr DN. et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 1998; 158: 585-593.
    CrossrefPubMedGoogle Scholar
  • 4 Glynn RJ, Rosner B. Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. Am J Epidemiol 2005; 162: 975-982.
    CrossrefPubMedGoogle Scholar
  • 5 White RH. The epidemiology of venous thromboembolism. Circulation 2003; 107: I4-8.
    PubMedGoogle Scholar
  • 6 World Health Organization. World Health Organization Global Status Report on alcohol. 2004 Avaliable at: http://www.who.int/substance_abuse/publications/global_status_report_2004_overview.pdf . Accessed May 15, 2010.
    PubMedGoogle Scholar
  • 7 Pace-Asciak CR, Hahn S, Diamandis EP. et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995; 235: 207-219.
    CrossrefPubMedGoogle Scholar
  • 8 Yarnell JW, Sweetnam PM, Rumley A. et al. Lifestyle and hemostatic risk factors for ischemic heart disease : the Caerphilly Study. Arterioscler Thromb Vasc Biol 2000; 20: 271-279.
    CrossrefPubMedGoogle Scholar
  • 9 Dimmitt SB, Rakic V, Puddey IB. et al. The effects of alcohol on coagulation and fibrinolytic factors: a controlled trial. Blood Coagul Fibrinolysis 1998; 9: 39-45.
    CrossrefPubMedGoogle Scholar
  • 10 Mukamal KJ, Jadhav PP, D’Agostino RB. et al. Alcohol consumption and hemostatic factors: analysis of the Framingham Offspring cohort. Circulation 2001; 104: 1367-1373.
    CrossrefPubMedGoogle Scholar
  • 11 Hvidtfeldt UA, Tolstrup JS, Jakobsen MU. et al. Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults. Circulation 2010; 121: 1589-1597.
    CrossrefPubMedGoogle Scholar
  • 12 Mukamal KJ, Chen CM, Rao SR. et al. Alcohol consumption and cardiovascular mortality among U.S. adults, 1987 to 2002. J Am Coll Cardiol 2010; 55: 1328-1335.
    CrossrefPubMedGoogle Scholar
  • 13 Pahor M, Guralnik JM, Havlik RJ. et al. Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons. J Am Geriatr Soc 1996; 44: 1030-1037.
    CrossrefPubMedGoogle Scholar
  • 14 Lutsey PL, Steffen LM, Virnig BA. et al. Diet and incident venous thromboembolism: the Iowa Women’s Health Study. Am Heart J 2009; 157: 1081-1087.
    CrossrefPubMedGoogle Scholar
  • 15 Lindqvist PG, Epstein E, Olsson H. The relationship between lifestyle factors and venous thromboembolism among women: a report from the MISS study. Br J Haematol 2009; 144: 234-240.
    CrossrefPubMedGoogle Scholar
  • 16 Pomp ER, Rosendaal FR, Doggen CJ. Alcohol consumption is associated with a decreased risk of venous thrombosis. Thromb Haemost 2008; 99: 59-63.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 17 Tsai AW, Cushman M, Rosamond WD. et al. Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. Arch Intern Med 2002; 162: 1182-1189.
    CrossrefPubMedGoogle Scholar
  • 18 Samama MM. An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med 2000; 160: 3415-3420.
    CrossrefPubMedGoogle Scholar
  • 19 Braekkan SK, Mathiesen EB, Njolstad I. et al. Mean platelet volume is a risk factor for venous thromboembolism: the Tromso Study, Tromso, Norway. J Thromb Haemost 2010; 8: 157-162.
    CrossrefPubMedGoogle Scholar
  • 20 Djousse L, Ellison RC, Beiser A. et al. Alcohol consumption and risk of ischemic stroke: The Framingham Study. Stroke 2002; 33: 907-912.
    CrossrefPubMedGoogle Scholar
  • 21 Friedman LA, Kimball AW. Coronary heart disease mortality and alcohol consumption in Framingham. Am J Epidemiol 1986; 124: 481-489.
    CrossrefPubMedGoogle Scholar
  • 22 Pendurthi UR, Williams JT, Rao LV. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. Arterioscler Thromb Vasc Biol 1999; 19: 419-426.
    CrossrefPubMedGoogle Scholar
  • 23 Gryglewski RJ, Korbut R, Robak J. et al. On the mechanism of antithrombotic action of flavonoids. Biochem Pharmacol 1987; 36: 317-322.
    CrossrefPubMedGoogle Scholar
  • 24 Klatsky AL. Alcohol and cardiovascular health. Physiol Behav 2010; 100: 76-81.
    CrossrefPubMedGoogle Scholar
  • 25 Pieters M, Vorster HH, Jerling JC. et al. The effect of ethanol and its metabolism on fibrinolysis. Thromb Haemost 2010; 104: 724-733.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 26 Mortensen EL, Jensen HH, Sanders SA. et al. Better psychological functioning and higher social status may largely explain the apparent health benefits of wine: a study of wine and beer drinking in young Danish adults. Arch Intern Med 2001; 161: 1844-1848.
    CrossrefPubMedGoogle Scholar
  • 27 Barefoot JC, Gronbaek M, Feaganes JR. et al. Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart Study. Am J Clin Nutr 2002; 76: 466-472.
    CrossrefPubMedGoogle Scholar
  • 28 Horverak Ø, Bye EK. The Norwegian drinking pattern. A study based on analyses of survey data from 1973-2004. Avaliable at: http://sirus.no/The+Norwegian+drinking+pattern.E2x322-8_Bp77BFv3TR9D6CJ1KWCUwlVPL28nMhPLZB9MtlY05hRDIX3.ips Accessed March 3, 2011.
    PubMedGoogle Scholar
  • 29 Statistics Norway. Statistics on alcohol sales, by type of beverage. Avaliable at: http://statbank.ssb.no/statistikkbanken/Default_FRasp?PXSid=0&nvl=true&PLanguage=1&tilside=selectvarval/define.asp&Tabellid=04188. Accessed March 3, 2011.
    PubMedGoogle Scholar
  • 30 Ruidavets JB, Bataille V, Dallongeville J. et al. Alcohol intake and diet in France, the prominent role of lifestyle. Eur Heart J 2004; 25: 1153-1162.
    CrossrefPubMedGoogle Scholar
  • 31 Khani BR, Ye W, Terry P. et al. Reproducibility and validity of major dietary patterns among Swedish women assessed with a food-frequency questionnaire. J Nutr 2004; 134: 1541-1545.
    CrossrefPubMedGoogle Scholar