Thromb Haemost 2011; 105(01): 40-44
DOI: 10.1160/TH10-05-0293
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation

Tetsushi Takemitsu
1   Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan
,
Hideo Wada
2   Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan
,
Tsuyoshi Hatada
3   Department of Emergency Medicine, Mie University Graduate School of Medicine, Tsu, Japan
,
Yukinari Ohmori
3   Department of Emergency Medicine, Mie University Graduate School of Medicine, Tsu, Japan
,
Ken Ishikura
3   Department of Emergency Medicine, Mie University Graduate School of Medicine, Tsu, Japan
,
Taichi Takeda
3   Department of Emergency Medicine, Mie University Graduate School of Medicine, Tsu, Japan
,
Takashi Sugiyama
4   Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan
,
Norikazu Yamada
5   Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
,
Kazuo Maruyama
6   Department of Anesthesia, Mie University Graduate School of Medicine, Tsu, Japan
,
Naoyuki Katayama
1   Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan
,
Shuji Isaji
7   Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan
,
Hideto Shimpo
8   Department of Cardiovascular Surgery, Mie University Graduate School of Medicine, Tsu, Japan
,
Masato Kusunoki
9   Department of Digestive Surgery, Mie University Graduate School of Medicine, Tsu, Japan
,
Tsutomu Nobori
2   Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan
› Author Affiliations
Further Information

Publication History

Received: 14 May 2010

Accepted after major revision: 23 September 2010

Publication Date:
22 November 2017 (online)

Summary

There are three different diagnostic score systems for disseminated intravascular coagulation (DIC) established by the Japanese Ministry Health and Welfare (JMHW), the International Society on Thrombosis and Haemostasis (ISTH) and the Japanese Association for Acute Medicine (JAAM). The JMHW criteria are still used in Japan. In the present study, all three diagnostic criteria were used to prospectively evaluate 413 patients with different underlying diseases of DIC who were treated at the Mie University Hospital (JMHW, n= 166; ISTH, n=143; JAAM, n=291). The odds ratio (95% confidence interval) for death was 1.88 (1.22 – 2.90) in JMHW, 2.55 (1.65 – 3.95) in ISHT and 1.99 (1.19 – 3.32) in JAAM. The platelet count, prothrombin time, fibrin and fibri-nogen degradation products and fibrinogen were significantly important for diagnosis of DIC by all three diagnostic criteria. Haemostatic molecular markers were significantly high in all patients and were useful for the diagnosis of DIC. The JAAM diagnostic criteria displayed a high sensitivity for DIC and the ISTH overt-DIC diagnostic criteria displayed a high specificity for DIC. All three diagnostic criteria for DIC were related to a poor patient outcome.

 
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