Tissue factor inhibition: Another approach reducing thrombosis after vascular injury

Thromb Haemost 2010; 103(01): 7-8
DOI: 10.1160/TH09-10-0712

Editorial Focus

Schattauer GmbH

Authors

Ilka Ott

¹1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

References
1 Wilcox JN, Smith KM, Schwartz SM. et al. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 1989; 86: 2839-2843.
2 Steppich B, Mattisek C, Sobczyk D. et al. Tissue factor pathway inhibitor on circulating microparticles in acute myocardial infarction. Thromb Haemost 2005; 93: 35-39.
3 Hoffman M, Monroe DM. 3rd. A cell-based model of hemostasis. Thromb Haemost 2001; 85: 958-965.
4 Himber J, Kirchhofer D, Riederer M. et al. Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function. Thromb Haemost 1997; 78: 1142-1149.
5 Morrow DA, Murphy SA, McCabe CH. et al. Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial. Eur Heart J 2005; 26: 682-688.
6 Jiao J-A, Kelly A, Marzec U. et al. Inhibition of acute vascular thrombosis in chimpanzees by an anti-human tissue factor antibody targeting the factor X binding site. Thromb Haemost 2009; 224-233.
7 Belting M, Ahamed J, Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol 2005; 25: 1545-1550.