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Thromb Haemost 2010; 103(01): 7-8
DOI: 10.1160/TH09-10-0712
Editorial Focus
Schattauer GmbH

Tissue factor inhibition: Another approach reducing thrombosis after vascular injury

Ilka Ott
1   1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
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Publication History

Received: 20 October 2009

Accepted: 20 October 2009

Publication Date:
22 November 2017 (online)

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  • References

  • 1 Wilcox JN, Smith KM, Schwartz SM. et al. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 1989; 86: 2839-2843.
    CrossrefPubMedSearch in Google Scholar
  • 2 Steppich B, Mattisek C, Sobczyk D. et al. Tissue factor pathway inhibitor on circulating microparticles in acute myocardial infarction. Thromb Haemost 2005; 93: 35-39.
    Thieme ConnectPubMedSearch in Google Scholar
  • 3 Hoffman M, Monroe DM. 3rd. A cell-based model of hemostasis. Thromb Haemost 2001; 85: 958-965.
    Thieme ConnectPubMedSearch in Google Scholar
  • 4 Himber J, Kirchhofer D, Riederer M. et al. Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function. Thromb Haemost 1997; 78: 1142-1149.
    Thieme ConnectPubMedSearch in Google Scholar
  • 5 Morrow DA, Murphy SA, McCabe CH. et al. Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial. Eur Heart J 2005; 26: 682-688.
    CrossrefPubMedSearch in Google Scholar
  • 6 Jiao J-A, Kelly A, Marzec U. et al. Inhibition of acute vascular thrombosis in chimpanzees by an anti-human tissue factor antibody targeting the factor X binding site. Thromb Haemost 2009; 224-233.
    PubMedSearch in Google Scholar
  • 7 Belting M, Ahamed J, Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol 2005; 25: 1545-1550.
    CrossrefPubMedSearch in Google Scholar