Activation of platelets in young infants during cardiopulmonary bypass

 

^* These authors contributed equally and share senior authorship.

• References

• 1 Weerasinghe A, Taylor KM. The platelet in cardio-pulmonary bypass. Ann Thorac Surg 1998; 66: 2145-2152.
• 2 Straub A, Wendel HP, Dietz K. et al. Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation. Thromb Haemost 2008; 99: 609-615.
• 3 Xavier RG, White AE, Fox SC. et al. Enhanced platelet aggregation and activation under conditions of hypothermia. Thromb Haemost 2007; 98: 1266-1275.
• 4 Gatti L, Guarneri D, Caccamo ML. et al. Platelet activation in newborns detected by flow-cytometry. Biol Neonate 1996; 70: 322-327.
• 5 Bednarek FJ, Bean S, Barnard MR. et al. The platelet hyporeactivity of extremely low birth weight neonates is age-dependent. Thromb Res 2009; 124: 42-45.
• 6 Ichinose F, Uezono S, Muto R. et al. Platelet hypo-reactivity in young infants during cardiopulmonary bypass. Anesth Analg 1999; 88: 258-262.
• 7 Peter K, Kohler B, Straub A. et al. Flow cytometric monitoring of glycoprotein IIb/IIIa blockade and platelet function in patients with acute myocardial infarction receiving reteplase, abciximab, and ticlopidine: continuous platelet inhibition by the combination of abciximab and ticlopidine. Circulation 2000; 102: 1490-1496.
• 8 Berndt MC, Karunakaran D, Gardiner EE. et al. Programmed autologous cleavage of platelet receptors. J Thromb Haemost 2007; 5 (Suppl. 01) 212-219.
• 9 Hourdille P, Heilmann E, Combrie R. et al. Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets. Blood 1990; 76: 1503-1513.
• 10 Horigome H, Hiramatsu Y, Shigeta O. et al. Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia. J Am Coll Cardiol 2002; 39: 1072-1077.
• 11 Fox SC, Behan MW, Heptinstall S. Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y₁₂ receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1. Cell Calcium 2004; 35: 39-46.
• 12 Cheung PY, Sawicki G, Salas E. et al. The mechanisms of platelet dysfunction during extracorporeal membrane oxygenation in critically ill neonates. Crit Care Med 2000; 28: 2584-2590.
• 13 Hiramatsu Y, Gikakis N, Anderson HL. 3rd, et al. Tirofiban provides ׳platelet anesthesia׳ during cardio-pulmonary bypass in baboons. J Thorac Cardiovasc Surg 1997; 113: 182-193.