Viral pathogens as novel activators of procoagulant signalling

• References

• 1 Alexopoulou L, Holt AC, Medzhitov R. et al. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413: 732-738.
• 2 Zhou L, Wang X, Wang YJ. et al. Activation of Toll-like receptor-3 induces interferon-lambda expression in human neuronal cells. Neuroscience 2009; 159: 629-637.
• 3 Jang YJ, Wang JH, Kim JS. et al. Levocetirizine inhibits rhinovirus-induced ICAM-1 and cytokine expression and viral replication in airway epithelial cells. Antiviral Res 2009; 81: 226-233.
• 4 Ciferska H, Horak P, Konttinen YT. et al. Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys--a preliminary pilot study. Lupus 2008; 17: 580-585.
• 5 Wornle M, Sauter M, Kastenmuller K. et al. Novel role of toll-like receptor 3, RIG-I and MDA5 in poly (I:C) RNA-induced mesothelial inflammation. Mol Cell Biochem. 2009; 322: 193-206.
• 6 Wörnle M, Sauter M, Kastenmüller K. et al. Role of TLR3, RIG-I and MDA5 in Mesothelial t-PA und PAI-1 Synthesis. Thromb Haemost 2009; 101: 1128-1137.
• 7 Shibamiya A, Hersemeyer K, Schmidt Wöll T. et al. A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells. Blood 2009; 113: 714-722.
• 8 Salomaa V, Stinson V, Kark JD. et al. Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation 1995; 91: 284-290.
• 9 Thogersen AM, Jansson JH, Boman K. et al. High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: evidence for the fibrinolytic system as an independent primary risk factor. Circulation 1998; 98: 2241-2247.
• 10 Pradhan AD, LaCroix AZ, Langer RD. et al. Tissue plasminogen activator antigen and D-dimer as markers for atherothrombotic risk among healthy postmenopausal women. Circulation 2004; 110: 292-300.
• 11 Fischer S, Nishio M, Peters SC. et al. Signaling mechanism of extracellular RNA in endothelial cells. FASEB J. 2009 in press.