Thromb Haemost 2008; 100(06): 960-961
DOI: 10.1160/TH08-10-0680
Editorial Focus
Schattauer GmbH

Leptin, obesity and platelet responsiveness: Another piece in the puzzle

Andrea Corsonello
1   Istituto Nazionale di Ricovero e Cura per Anziani (INRCA), Cosenza, Italy
,
Francesco Corica
2   Dipartimento di Medicina Interna, Università degli Studi di Messina, Messina, Italy
› Author Affiliations
Further Information

Publication History

Received: 22 October 2008

Accepted: 22 October 2008

Publication Date:
23 November 2017 (online)

 

 
  • References

  • 1 Dellas C, Schäfer K, Rohm I. et al. Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. Thromb Haemost 2008; 100: 1123-1129.
  • 2 Corica F, Corsonello A, Lucchetti M. et al. Relationship between metabolic syndrome and platelet responsiveness to leptin in overweight and obese patients. Int J Obes (Lond) 2007; 31: 842-849.
  • 3 Canavan B, Salem RO, Schurgin S. et al. Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation. J Clin Endocrinol Metab 2005; 90: 5779-5785.
  • 4 Gresele P, Falcinelli E, Momi S. Potentiation and priming of platelet activation: a potential target for antiplatelet therapy. Trends Pharmacol Sci 2008; 29: 352-360.
  • 5 Gertler A. Development of leptin anatagonists and their potential use in experimental biology and medicine. Trends Endocrinol. Metab 2006; 17: 372-378.
  • 6 Wallace AM, McMahon AD, Packard CJ. et al. Plasma leptin and the risk of cardiovascular disease in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 2001; 104: 3052-3056.
  • 7 Wolk R, Berger P, Lennon RJ. et al. Plasma leptin and prognosis in patients with established coronary atherosclerosis. J Am Coll Cardiol 2004; 44: 1819-1824.
  • 8 Bodary PF, Westrick RJ, Wickenheiser KJ. et al. Effect of leptin on arterial thrombosis following vascular injury in mice. J Am Med Assoc 2002; 287: 1706-1709.