An oral vitamin K protocol to reverse over-anticoagulation in patients presenting with an International Normalised Ratio above 10.0

Thromb Haemost 2009; 101(02): 410-411
DOI: 10.1160/TH08-04-0251

Letters to the Editor

Schattauer GmbH

Gentian Denas

¹Clinical Cardiology, Thrombosis Center, Department of Cardiothoracic and Vascular Sciences, University of Padova School of Medicine, Padova, Italy

,

Umberto Cucchini

¹Clinical Cardiology, Thrombosis Center, Department of Cardiothoracic and Vascular Sciences, University of Padova School of Medicine, Padova, Italy

,

Sabino Iliceto

¹Clinical Cardiology, Thrombosis Center, Department of Cardiothoracic and Vascular Sciences, University of Padova School of Medicine, Padova, Italy

,

Vittorio Pengo

¹Clinical Cardiology, Thrombosis Center, Department of Cardiothoracic and Vascular Sciences, University of Padova School of Medicine, Padova, Italy

References
1 Denas G, Marzot F, Offelli P. et al. Effectiveness and safety of a management protocol to correct over-anticoagulation with oral vitamin K: a retrospective study of 1,043 cases. J Thromb Thrombolysis. 2008 in print.
2 Palareti G, Leali N, Coccheri S. et al. Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (IS-COAT). Italian Study on Complications of Oral Anticoagulant Therapy. Lancet 1996; 348: 423-428.
3 Dentali F, Ageno W. Management of coumarin-associated coagulopathy in the non-bleeding patient: a systematic review. Haematologica 2004; 89: 857-862.
4 Dezee KJ, Shimeall WT, Douglas KM, Shumway NM, O’Malley PG. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch Intern Med 2006; 166: 391-397.
5 Libby EN, Garcia DA. A survey of oral vitamin K use by anticoagulation clinics. Arch Intern Med 2002; 162: 1893-1896.
6 Gunther KE, Conway G, Leibach L. et al. Low-dose oral vitamin K is safe and effective for outpatient management of patients with an INR>10. Thromb Res 2004; 113: 205-209.
7 Ansell J, Hirsh J, Hylek E. et al. Pharmacology and Management of the Vitamin K Antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 160S-198.
8 Makris M, Watson HG. The management of cou-marin-induced over-anticoagulation. Annotation. Br J Haemat 2001; 114: 271-280.