Haematopoietic growth factors and their therapeutic use

Meenu Wadhwa; Robin Thorpe

doi:10.1160/TH07-11-0703

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2008; 99(05): 863-873
DOI: 10.1160/TH07-11-0703

Theme Issue Article

Schattauer GmbH

Haematopoietic growth factors and their therapeutic use

Meenu Wadhwa

¹Biotherapeutics Group, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, United Kingdom

,

Robin Thorpe

¹Biotherapeutics Group, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, United Kingdom

› Author Affiliations

Abstract

Summary

Haematopoietic growth factors constitute an important group of proteins that predominantly regulate the process of haematopoiesis. While some of these proteins have a very broad array of action on very early haematopoietic progenitors leading to multi-lineage increases in haematopoietic cell production and differentiation, others act in a restricted manner on specific committed terminally differentiated cell types. On the basis of their unique spectrum of activities, several factors are approved for clinical use in various indications while others are under investigation in the clinic either alone or as combination therapy. In this review, we have described factors which directly and in some cases indirectly influence haematopoiesis with particular focus on those factors which are either approved or show potential for clinical use. A brief description of the products that are currently available for clinical use is also provided. At present, several new products which include fusion proteins, peptide mimetics are either at the pre-clinical stage or in clinical development for various indications and these are also briefly described.

Keywords

Haematopoiesis - second-generation - biosimilars - stem cells - adverse

Full Text

References

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