Thromb Haemost 2008; 99(06): 995-1000
DOI: 10.1160/TH07-11-0682
Review Article
Schattauer GmbH

Metabolic syndrome, haemostasis and thrombosis

Marie-Christine Alessi
1   Laboratoire d’Hématologie, Faculté de Médecine, Université de la Méditerranée, Inserm UMR 626, Marseille, France
Irène Juhan-Vague
1   Laboratoire d’Hématologie, Faculté de Médecine, Université de la Méditerranée, Inserm UMR 626, Marseille, France
› Author Affiliations
Further Information

Publication History

Received 16 November 2007

Accepted after major revision 25 April 2008

Publication Date:
28 November 2017 (online)


The metabolic syndrome (metS), a concurrence of abdominal fat, disturbed glucose and insulin metabolism, dyslipidemia, and hypertension has been strongly associated not only with subsequent development of type 2 diabetes but also with athero-thrombosis. The physiopathology of this association is complex. The metS affects the thrombogenicity of circulating blood. Apart from its effect on platelets, a procoagulant and hypofibrinolytic state has been identified; mainly the result of the inflammatory state, dyslipidemia, and liver fat accumulation that accompany the MetS. Among haemostasis disturbances, the strong rise in the inhibitor of plasminogen activator type 1 plasma level is the most documented abnormality implicating the participation of the oxidative stress and inflammatory state developed during the metS. Endothelial dysfunction is also a central feature. Moreover, secretion products of fat tissues (adipokines) are now thought to have direct modulating effects on the vascular and the circulating cells. In support of these data, the metS, may predispose not only to atherosclerosis but also to venous thrombosis.

This review article is the last contribution to the March 2008 Theme issue in connection with the GTH congress in Wiesbaden, Germany.

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