Thromb Haemost 2008; 99(03): 637-639
DOI: 10.1160/TH07-07-0465
Letters to the Editor
Schattauer GmbH

Effects of diabetes mellitus on platelet reactivity after dual antiplatelet therapy with aspirin and clopidogrel

Jochem W. van Werkum*
1   Department of Cardiology
,
Yasemin Topcu*
1   Department of Cardiology
,
Sonja Postma
2   Department of Clinical Chemistry, St. Antonius Hospital, Nieuwegein, the Netherlands
,
Johannes C. Kelder
1   Department of Cardiology
,
Christian M. Hackeng
2   Department of Clinical Chemistry, St. Antonius Hospital, Nieuwegein, the Netherlands
,
Jurrien M. ten Berg
1   Department of Cardiology
,
Freek W. A. Verheugt
3   Department of Cardiology, UMC Nijmegen, The Netherlands
› Author Affiliations
Further Information

Publication History

Received: 23 July 2007

Accepted after major revision: 23 January 2008

Publication Date:
07 December 2017 (online)

 

Notes

* Both authors contributed equally to this manuscript.


 
  • References

  • 1 Steinhubl SR, Berger PB, Mann JT. III et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. J Am Med Assoc 2002; 288: 2411-2420.
  • 2 Serebruany VL, Steinhubl SR, Berger PB. et al. Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol 2005; 45: 246-251.
  • 3 Van Werkum JW, Heestermans AACM, Deneer VHM. et al. Clopidogrel resistance: fact or fiction?. Future Cardiol 2006; 2: 215-228.
  • 4 Sibbing D, von Beckerath O, Schomig A. et al. Diabetes mellitus and platelet function after administration of aspirin and a single 600 mg dose of clopidogrel. J Thromb Haemost 2006; 4: 2566-2568.
  • 5 Angiolillo DJ, Fernandez-Ortiz A, Bernardo E. et al. Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 2005; 54: 2430-2435.
  • 6 Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539-553.
  • 7 von Beckerath N, Pogatsa-Murray G, Wieczorek A. et al. Correlation of a new point-of-care test with conventional optical aggregometry for the assessment of clopidogrel responsiveness. Thromb Haemost 2006; 95: 910-911.
  • 8 Van Werkum JW, van der Stelt CA, Seesing TH. et al. A head-to-head comparison between the VerifyNow P2Y12 assay and light transmittance aggregometry for monitoring the individual platelet response to clopidogrel in patients undergoing elective percutaneous coronary intervention. J Thromb Haemost 2006; 4: 2516-2518.
  • 9 Geisler T, Anders N, Paterok M. et al. Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation. Diabetes Care 2007; 30: 372-374.
  • 10 Michelson AD, Linden MD, Furman MI. et al. Evidence that pre-existent variability in platelet response to ADP accounts for ‘clopidogrel resistance’. J Thromb Haemost 2007; 5: 75-81.
  • 11 Gurbel PA, Bliden KP, Hiatt BL. et al. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 2003; 107: 2908-2913.
  • 12 Frere C, Cuisset T, Quilici J. et al. ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome. Thromb Haemost 2007; 98: 838-843.