Reminiscences of my contributions to Thrombosis and Haemostasis: Urine tissue factor and plasma plasmin inhibitor

• References

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• 2 Caldwell J, von Kaulla KN, von Kaulla E. et al. Procoagulant material from human urine in prothrombin activation. Thromb Diath Haemorrh 1963; 9: 53-61.
• 3 Aoki N, von Kaulla KN. Theprocoagulant in human urine: Purification, assay and some biochemical and physiological properties. Thromb Diath Haemorrh 1966; 16: 586-605.
• 4 Aoki N, von Kaulla KN. Partial purification and characterization of urinary procoagulant. Thromb Diath Haemorrh 1971; 26: 235-250.
• 5 Matsuda M, Aoki N. Purification and characterization of procoagulant in human urine. Thromb Res 1978; 13: 311-324.
• 6 Kurosawa S, Matsuda M, Aoki N. Urinary procoagulant behaves as tissue factor by promoting factor VIIa-catalyzed activation of factor X. Thromb Res 1984; 33: 595-606.
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• 26 Lwaleed BA, Bass PS, Chisholm M. et al. Urinary tissue factor in glomerulonephritis: a potential marker of glomerular injury?. J Clin Pathol 1997; 50: 336-340.
• 27 Koyama T, Ohdama S, Aoki N. Plasma tissue factor reflects endothelial cell injury rather than upregulation of tissue factor expression. Thromb Haemost 1997; 78: 972.
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• 30 Moroi M, Aoki N. Isolationand characterization of α2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis. J Biol Chem 1976; 251: 5956-5965.
• 31 Aoki N, Moroi M, Matsuda M. et al. The behavior of α2-plasmin inhibitor in fibrinolytic states. J Clin Invest 1977; 60: 361-369.
• 32 Saito H, Goldsmith GH, Moroi M. et al. Inhibitory spectrum of α2-plasm ininhibitor. Proc Natl Acad Sci USA 1979; 76: 2013-2017.
• 33 Gallimore MJ. Serum inhibitors of fibrinolysis. Br J Haematol 1975; 31: 217-231.
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• 38 Yoshinaga H, Hirosawa S, Chung DH. et al. A novel point mutation of the splicing donor site in theintron 2 of the plasmin inhibitor gene. Thromb Haemost 2000; 84: 307-311.
• 39 Yoshinaga H, Nakahara M, Koyama T. et al. A single thymine nucleotide deletion responsible for congenital deficiency of plasmini nhibitor. Thromb Haemost 2002; 88: 144-148.
• 40 Aoki N. Thepast, present and future of plasmin inhibitor. Thromb Res 2005; 116: 455-464.
• 41 Wiman B, Collen D. Purification and characterization of human antiplasmin, thefast-acting plasmin inhibitor in plasma. Eur J Biochem 1977; 78: 19-26.
• 42 Yamanaka T, Ido K, Kimura K. et al. Alpha2-plasmin inhibitor levels in liver diseases. Igaku No Ayumi 1977; 103: 74-77.
• 43 Aoki N, Yamanaka T. The α2-plasmin inhibitor levels in liver diseases. Clin Chim Acta 1978; 84: 99-105.
• 44 Moroi M, Aoki N. Inhibition of plasminogen binding to fibrin by α2-plasmin inhibitor. Thromb Res 1977; 10: 851-856.
• 45 Aoki N, Moroi M, Tachiya K. Effects of α2-plasmin inhibitor on fibrinclotlysis. Its comparison with α2-macroglobulin. Thromb Haemost 1978; 39: 22-31.
• 46 Sakata Y, Aoki N. Cross-linking of α2-plasmin inhibitort of ibrin by fibrin-stabilizing factor. J Clin Invest 1980; 65: 290-297.
• 47 Sakata Y, Aoki N. Significance of cross-linking of α2-plasmin inhibitor to fibrin in inhibition of fibrinolysis and hemostasis. J Clin Invest 1982; 69: 536-542.
• 48 Aoki N. Clotretraction increases clot resistance to fibrinolysis by condensing α2-plasmin inhibitor cross linked to fibrin. Thromb Haemost 1993; 70: 376.
• 49 Tamaki T, Aoki N. Cross-linking of α2-plasmin inhibitort of ibrin catalyzed by activated fibrin-stabilizing factor. J Biol Chem 1982; 257: 14767-14772.
• 50 Kimura S, Aoki N. Cross-linking site in fibrinogen for α2-plasmin inhibitor. J Biol Chem 1986; 261: 15591-15595.
• 51 Aoki N, Saito H, Kamiya T. et al. Congenital deficiency of α2-plasmin inhibitor associated with severe hemorrhagic tendency. J Clin Invest 1979; 63: 877-884.
• 52 Aoki N, Sakata Y, Matsuda M. et al. Fibrinolytic states in a patient with congenital deficiency of α2-plasmin inhibitor. Blood 1980; 55: 483-488.
• 53 Aoki N, Sakata Y, Ichinose A. Fibrin-associated plasminogen activation in α2-plasmin inhibitor deficiency. Blood 1983; 62: 1118-1122.
• 54 Miura O, Sugahara Y, Aoki N. Hereditary α2-plasmin inhibitor deficiency caused by a transport-deficient mutation(α2PI-Okinawa). J Biol Chem 1989; 264: 18213-18219.
• 55 Miura O, Hirosawa S, Kato A. et al. Molecular basis for congenital deficiency of α2-plasmin inhibitor. J Clin Invest 1989; 83: 1598-1604.
• 56 Miura O, Aoki N. Impaired secretion of mutant α2-plasmin inhibitor(α2PI-Nara) from COS-7and HepG2cells: molecular and cellular basis for hereditary deficiency of α2-plasmin inhibitor. Blood 1990; 75: 1092-1096.
• 57 Sugahara Y, Miura O, Yuen P. et al. Protein C deficiency caused by two mutant alleles, a5-nucleotide deletion and amissence mutation. Blood 1992; 80: 126-133.
• 58 Miura O, Sugahara Y, Aoki N. Intracellular transport-deficient mutants causing hereditary deficiencies of factors involved in coagulation and fibrinolysis. Thromb Haemost 1993; 69: 296-297.
• 59 Aoki N. Discovery of α2-plasmin inhibitor and its congenital deficiency. J Thromb Haemost 2005; 3: 623-631.
• 60 Gallimore MJ. More on: discovery of α2-plasmin inhibitorand its congenital deficiency. J Thromb Haemost 2006; 4: 284-285.
• 61 Sumi Y, Ichikawa Y, Nakamura Y. et al. Expression and characterization of pro α2-plasmin inhibitor. J Biochem 1989; 106: 703-707.
• 62 Bangert K, Johnsen AH, Christensen U. et al. Different N-terminal forms of α2-plasmin inhibitorin human plasma. Biochem J 1993; 291: 623-625.
• 63 Koyama T, Koike Y, Toyota S. et al. Different NH2-terminal form with 12 additional residues of α2-plasmin inhibitor from human plasma and culture media of Hep G2 cells. Biochem Biophys Res Commun 1994; 200: 417-422.
• 64 Lee KN, Jackson KW, Christiansen VJ. et al. A novel plasma proteinase potentiates α2-antiplasmin inhibition of fibrin digestion. Blood 2004; 103: 3783-3788.
• 65 Lee KN, Jackson KW, Christiansen VJ. et al. Anti-plasmin-cleaving enzyme is a soluble form of fibrob-last activation protein. Blood 2006; 107: 1397-1404.
• 66 Christiansen VJ, Jackson KW, Lee KN. et al. The effect of a single nucleotide polymorphism on human α2-antiplasminactivity. Blood online Feb 22,. 2007 doi:10.1182/blood-2007-01-065185.
• 67 Okajima K, Koga S, Kaji M. et al. Effect of protein C and activated protein C on coagulation and fibrinolysis in normal human subjects. Thromb Haemost 1990; 63: 48-53.
• 68 Aoki N, Matsuda T, Saito H. et al. A comparative double-blind randomized trial of activated protein C and unfractionated heparin in the treatment of disseminated intravascular coagulation. Int J Hematol 2002; 75: 540-547.
• 69 Ohdama S, Aoki N. Increase of plasma thrombomodulin in systemic vasculitis. Thromb Haemost 1997; 77: 609.
• 70 Ohdama S, Takano S, Miyake S. et al. Plasma thrombomodulin as a marker of vascular injuries in collagen vascular diseases. Am J Clin Pathol 1994; 101: 109-113.
• 71 Ohdama S, Matsubara O, Aoki N. Plasma thrombomodulin in Wegener’s granulomatosis as an indicator of vascular injuries. Chest 1994; 106: 666-671.