Thromb Haemost 2007; 97(05): 755-762
DOI: 10.1160/TH07-01-0040
Theme Issue Article
Schattauer GmbH

Chemokines as mediators of angiogenesis

Borna Mehrad
1  Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA
,
Michael P. Keane
2  Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA
,
Robert M. Strieter
1  Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA
› Author Affiliations
Financial support: This work was supported by NIH grants HL73848 and an American Lung Association Career Investigator Award (Mehrad), AR055075 (Keane), and CA87879 and HL66027 (Strieter).
Further Information

Publication History

Received 21 January 2007

Accepted after revision 05 March 2007

Publication Date:
24 November 2017 (online)

Summary

Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation. Members of a subgroup of chemokines, the CXC family, also play a critical role in both physiologic and pathologic angiogenesis, including in the context of chronic inflammation, fibrosis, and malignancy.A unique feature of this family of cytokines is that, on the basis of their structure and receptor binding, individual ligands display either angiogenic or angiostatic biological activity in the regulation of angiogenesis. In this review, we summarize the key literature in this growing field.