Comment on: “The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia” by Spiel et al.

• References

• 1 Spiel AO, Firbas C, Mayr FB. et al. The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia. Thromb Haemost 2005; 94: 1148-55.
• 2 Memos N, Adamidis V, Frantzeskaki F. et al. Protein C zymogen infusion reduces inflammation and apoptotic proteins expression in septic rat lung [Abstr]. 18th annual congress, European Society of Intensive Care Medicine S72.
• 3 Betrosian A, Balla M, Kofinas G. et al. ProteinC in the treatment of coagulopathy in meningococcal sepsis. Crit Care Med 1999; 27: 2849-50.
• 4 White B, Livingstone W, Murphy C. et al. An openlabel study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura ful-minans-associated meningococcemia. Blood 2000; 96: 3719-24.
• 5 Rintala E, Kauppila M, Seppala OP. et al. ProteinC substitution in sepsis-associated purpura fulminans. Crit Care Med 2000; 28: 2373-8.