Inihibition of cytokine response by methylprednisolone attenuates antithrombin reduction following hepatic resection

• References

• 1 Teoh N, Farrell GC. Hepatic ischemia reperfusion injury. Pathogenic mechanism and basis for Hepatoprotection. J Gastroenterol Hepatol 2003; 18: 891-902
• 2 Kragsbjerg P, Holmberg H, Vikerfors T. Serum concentrations of Interleukin-6, Tumor Necrosis Factor-a, and C-reactive Protein in Patients Undergoing Major Operations. Eur J Surg 1995; 161: 17-22
• 3 Patel RT, Deen KI, Youngs D. et al Interleukin-6 is a prognostic indicator of outcome in severe intra-abdominal sepsis. Br J Surg 1994; 81: 1306-8
• 4 Biffi Wl, Moore EE, Moore FA. et al Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation ?. Ann Surg 1996; 224: 647-64
• 5 Tsuji K, Eguchi y, Kodama M. Postoperative hypercoagulable state followed by hyperfibrinolysis related to wound healing after hepatic resection. J Am Coll Surg 1996; 183: 230-8
• 6 Sinischalchi A, Begliomini B, De Pietri L. et al I Increased prothrombin time and platelet counts in living donor right hepatectomy: implications for epidural anesthesia. Liver Transpl 2004; 10: 1144-9
• 7 Rosenberg RD. Biochemistry of heparin antithrombin interactions, and the physiologic role of this natural anticoagulant mechanism. Am J Med 1989; 87: 2S-9S.
• 8 Wilson R, Mammen E, Robson M. et al Antithrombin, prekalikrein, and fibronectn levels in surgical patients. Arch. Surg 1986; 121: 635-40
• 9 Hashimoto K, Yamagishi M, Sasaki T. et al Heparin and antithrombin III levels during cardiopulmonary bypass: Correlation with subclinical plasma coagulation. Ann Thorac Surg 1994; 58: 804-5
• 10 Roemisch J, Gray E, Hoffmann JN. et al Antithrombin: a new look at the actions of a serine protease inhibitor. 2002; 13: 657-70.
• 11 Harada N, Okajima K, Uchiba M. et al Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1. Thromb Haemost 2004; 92: 550-8
• 12 Shimada M, Matsumata T, Kamakura T. et al Modulation of coagulation and fibrinolysis in hepatic resection: A randomized prospective control study using antithrombin III concentrates. Thromb Res 1994; 74: 105-14
• 13 Muratore A, Ribero D, Ferrero A. et al Prospective randomized study of steroids in the prevention of ischaemic injury durino hepatic resection with pedicle camping. Br J Surg 2003; 90: 17-22
• 14 Stouthard JM, Levi M, Hack CE. et al Interleukin-6 stimulates coagulation, not fibrinolysis, in humans. Thromb Haemost 1996; 76: 738-42
• 15 Matsutani T, Onda M, Sasajima K. et al Glucocorticoid attenuates a decrease of antithrombin III following major surgery. J Surg Res 1998; 79: 158-6