Structure, function and biology of tissue factor pathway inhibitor-2

Hitendra S. Chand; Donald C. Foster; Walter Kisiel

doi:10.1160/TH05-07-0509

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2005; 94(06): 1122-1130
DOI: 10.1160/TH05-07-0509

Review Article

Schattauer GmbH

Structure, function and biology of tissue factor pathway inhibitor-2

Hitendra S. Chand

¹Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, and

,

Donald C. Foster

²Zymo Genetics, Inc., Seattle, Washington, USA

,

Walter Kisiel

¹Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, and

› Author Affiliations

Abstract

Summary

Tissue factor pathway inhibitor-2 (TFPI-2) is a 32 kDa matrix-associated Kunitz-type serine proteinase inhibitor consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. Human TFPI-2, previously designated as placental protein 5, inhibits a broad spectrum of serine proteinases almost exclusively through its first Kunitz-type domain, and is thought to play an important role in the regulation of extracellular matrix digestion and re-modeling. In this context, reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth/metastasis. In this review, we document current information regarding the expression of TFPI-2 by various tissues, its inhibitory activity and proteinase specificity in-vitro, and discuss possible physiological roles for this inhibitor based on in-vivo studies.

Keywords

Tissue factor pathway inhibitor-2 - tumor - metastasis - mutagenesis - X-ray crystallographys

Full Text

References

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