Bone morphogenetic proteins and vascular differentiation

Martin Moser; Cam Patterson

doi:10.1160/TH05-05-0312

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2005; 94(04): 713-718
DOI: 10.1160/TH05-05-0312

Theme Issue Article

Schattauer GmbH

Bone morphogenetic proteins and vascular differentiation

BMPing up vasculogenesis

Authors

Martin Moser

¹Department of Cardiology, University of Freiburg, Germany
Cam Patterson

²2Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, USA

Abstract

Summary

Vasculogenesis is an important mechanism of blood vessel formation not only in embryos but also in adults. It may contribute to reparative effects of progenitor cell therapy in ischemic diseases such as myocardial infarction. Signaling pathways involved in embryonic development, including the BMP pathway, are reactivated in adult vasculogenesis. As a consequence knowledge about embryonic signaling events will help to understand blood vessel formation in the adult. The role of BMPs in embryonic development has been studied extensively in the past decades but only recently their role in vasculogenesis has been recognized. Gain and loss of function models indicate that BMPs stimulate vasculogenesis in the embryo as well as in the adult. Additionally, BMPs interact with other pathways involved in blood vessel formation, such as VEGF signaling. Studying novel molecules such as BMPER that modulate BMP activity and that are expressed in vascular cells will help to understand vasculogenetic signaling and may open up new therapeutic avenues in vascular disease.

Keywords

Bone morphogenetic proteins - vasculogenesis - novel proteins

Full Text

References

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