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Thromb Haemost 2005; 94(02): 427-431
DOI: 10.1160/TH04-12-0811
Wound Healing and Inflammation/Infection
Schattauer GmbH

Genotype-specific increase in plasma concentrations of activated coagulation factor VII in response to experimental inflammation

A link between infection and acute myocardial infarction?
Marie Bennermo
1   Department of Medicine, Danderyd University Hospital
,
Claes Held
2   Department of Cardiology
,
Carl-Göran Ericsson
1   Department of Medicine, Danderyd University Hospital
,
Angela Silveira
3   Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden
,
Anders Hamsten
2   Department of Cardiology
3   Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden
,
Per Tornvall
2   Department of Cardiology
3   Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden
› Author Affiliations
Further Information

Publication History

Received: 16 December 2004

Accepted after major revision: 19 May 2005

Publication Date:
05 December 2017 (online)

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Summary

There is evidence that infection and inflammation might trigger an acute coronary event, but the mechanisms are unclear. Activated factor VII (FVIIa) is a potent coagulant that is under genetic control and a potential determinant of the outcome of acute myocardial infarction. This study investigated the acute FVIIa response to experimental inflammation. Forty healthy men and women were vaccinated with 1 ml of Salmonella Typhii vaccine. Plasma levels of FVIIa, FVII antigen (FVIIag), tissue factor (TF) activity and thrombin-antithrombin complex (TAT) were measured at baseline and up to 24 hours after inoculation. All subjects were genotyped for the FVII gene Arg353Gln polymorphism. Plasma concentrations of FVIIa, but not FVIIag, increased significantly with a peak at 10 hrs after vaccination. At 24 hrs FVIIa levels had returned to baseline. The FVIIa response to vaccination was significantly greater in subjects with the ArgArg genotype compared with ArgGln subjects.TAT increased, butTF activity was unchanged after vaccination. The results are of interest from a mechanistic viewpoint, since one explanation for the link between infection and acute myocardial infarction might be activation of coagulation. However, there is a need for further studies of the role of infection and inflammation in haemostasis.

Keywords

Gene regulation - inflammatory mediators - tissue factor/factorVII
 

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