Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression

Li Yan; Stanley Zucker; Bryan P. Toole

doi:10.1160/TH04-08-0536

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2005; 93(02): 199-204
DOI: 10.1160/TH04-08-0536

Theme Issue Article

Schattauer GmbH

Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression

Li Yan

¹Oncology, Centocor Inc, Radnor, Pennsylvania, USA

,

Stanley Zucker

²Research and Medicine, Veterans Affairs Medical Center, Northport, New York, USA

,

Bryan P. Toole

³Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina, USA

› Author Affiliations

Abstract

Summary

Emmprin (basigin;CD147) is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of malignant tumour cells. Emmprin is involved in numerous physiological and pathological systems and exhibits several molecular and cellular characteristics, but a major function of emmprin is stimulation of synthesis of several matrix metalloproteinases. In tumours, emmprin most likely stimulates matrix metalloproteinase production in stromal fibroblasts and endothelial cells as well as in tumour cells themselves by a mechanism involving homophilic interactions between emmprin molecules on apposing cells or on neighbouring cells after membrane vesicle shedding. Membrane-associated cofactors, including caveolin-1 and annexin II, regulate emmprin activity. Emmprin induces angiogenesis via stimulation of VEGF production, invasiveness via stimulation of matrix metalloproteinase production and multidrug resistance via hyaluronan-mediated up-regulation of ErbB2 signaling and cell survival pathway activities. Although the detailed mechanisms whereby it regulates these numerous phenomena are not yet known, it is clear that emmprin is a major mediator of malignant cell behavior.

Keywords

Matrix metalloproteinases - angiogenesis - invasiveness - chemoresistance - tumour-stroma interaction

Full Text

References

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