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Thromb Haemost 2004; 92(06): 1182-1193
DOI: 10.1160/TH04-05-0289
Theme Issue Article
Schattauer GmbH

Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease

Richard C. Becker
1   Duke Cardiovascular Thrombosis Center, Duke University Medical Center, Durham, North Carolina, USA
2   Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
,
John Alexander
1   Duke Cardiovascular Thrombosis Center, Duke University Medical Center, Durham, North Carolina, USA
2   Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
,
Christopher K. Dyke
1   Duke Cardiovascular Thrombosis Center, Duke University Medical Center, Durham, North Carolina, USA
2   Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
,
Robert A. Harrington
1   Duke Cardiovascular Thrombosis Center, Duke University Medical Center, Durham, North Carolina, USA
2   Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
› Author Affiliations
Further Information

Publication History

Received 10 May 2004

Accepted after revision 04 October 2004

Publication Date:
02 December 2017 (online)

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Summary

The development of anticoagulants for treating patients with atherothrombotic disorders of the arterial circulatory system has focused, either directly or indirectly, on thrombin – a pleuripotential effector enzyme with prothrombotic and proinflammatory properties. The pivotal role of factor (f) Xa in thrombin generation, coupled with its direct cellular effects and widely recognized limitations of currently available anticoagulants, has led to the development of pharmacologic inhibitors of this important protease. The following review focuses on DX9065a – first in a class of direct, selective and reversible fXa antagonists – and its potential applications in the management of patients with cardiovascular disease.

Keywords

DX-9065a - Factor Xa - antagonist
 

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