Thromb Haemost 2004; 92(04): 738-746
DOI: 10.1160/TH04-03-0163
Theme Issue Article
Schattauer GmbH

The use of rFVIIa in non-haemophilia bleeding conditions in paediatrics

A systematic review
Prasad Mathew
1   University of New Mexico, Department of Pediatrics, Albuquerque, New Mexico, USA
› Author Affiliations
Further Information

Publication History

Received 15 March 2004

Accepted after resubmission 04 June 2004

Publication Date:
06 December 2017 (online)

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Summary

From its original envisioned use in patients with hemophilia and inhibitors, recombinant factor VIIa has been increasingly used in a variety of non-hemophilia bleeding/hemorrhagic situations with great efficacy. Most of the reported work has been in adult patients. This paper sets out to review its use in the pediatric non-hemophilia patients and the varied conditions it has been tried and used. Most of the published literature has shown that this agent is efficacious, safe and can be used as an adjunctive measure in the achievement of hemostasis. However, most of the published work is mainly anecdotal, case reports or small series. Randomized trials in children are eagerly awaited.

* On behalf of the Scientific and Standardization Committee on Perinatal/Pediatric Hemostasis, ISTH. Presented in part at the SSC committee meeting, ISTH, Birmingham 2003.