Platelet glycoprotein Ibα polymorphisms modulate the risk for myocardial infarction

Margareth C. Ozelo; Andrea F. Origa; Francisco J. P. Aranha; Antonio P. Mansur; Joyce M. Annichino-Bizzacchi; Fernando F. Costa; Eleanor S. Pollak; Valder R. Arruda

doi:10.1160/TH03-12-0744

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(02): 384-386
DOI: 10.1160/TH03-12-0744

Platelets and Blood Cells

Schattauer GmbH

Platelet glycoprotein Ibα polymorphisms modulate the risk for myocardial infarction

Margareth C. Ozelo

¹State University of Campinas, Campinas, Brazil

,

Andrea F. Origa

¹State University of Campinas, Campinas, Brazil

,

Francisco J. P. Aranha

¹State University of Campinas, Campinas, Brazil

,

Antonio P. Mansur

²University of São Paulo, São Paulo, Brazil

,

Joyce M. Annichino-Bizzacchi

¹State University of Campinas, Campinas, Brazil

,

Fernando F. Costa

¹State University of Campinas, Campinas, Brazil

,

Eleanor S. Pollak

³University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

,

Valder R. Arruda

³University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

⁴The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

› Author Affiliations

Abstract

Summary

Platelet glycoprotein Iba (GPIba) gene polymorphisms have been reported to affect the risk of developing coronary heart disease. Here, within the GPIba gene, we determine the association between the variable number of tandem repeats (VNTR), the -5C/T Kozak sequence dimorphism, and the human platelet antigen (HPA)-2 polymorphisms with occurrence of myocardial infarction (MI). Patients (n=180) presenting survivors of MI were compared to 180 controls matched by age, gender, and race. Carriers of VNTR-CD genotype had a 2-fold higher risk for MI compared to controls. The prevalence of VNTR-BC was lower among patients than among controls (P=.007). These data are in agreement with recent reports of increased plug formation by human platelets containing VNTRCD but no other VNTR genotypes. Among patients, the number of vessels severely occluded was greater among carriers of the D-allele (P=.019) or VNTR-CD (P=.026) and lower among carriers of the C-allele (P=.003) or VNTR-CC (P=.0009) compared to non-carriers of these alleles. No influence was seen with the Kozak or HPA-2 polymorphisms. Determination of VNTR of the GPIba gene may prove useful for identifying high-risk individuals for MI.

Keywords

Arterial disease - coronary heart disease - myocardial infarction - platelet glycoprotein Ibα - polymorphism VNTR

Full Text

References

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