Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina

Hidetomo Maruyoshi; Sunao Kojima; Tohru Funahashi; Shinzo Miyamoto; Jun Hokamaki; Hirofumi Soejima; Tomohiro Sakamoto; Hiroaki Kawano; Michihiro Yoshimura; Akira Kitagawa; Yuji Matsuzawa; Hisao Ogawa

doi:10.1160/TH03-12-0731

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 91(05): 1026-1030
DOI: 10.1160/TH03-12-0731

Cell Signaling and Vessel Remodeling

Schattauer GmbH

Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina

Authors

Hidetomo Maruyoshi

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Sunao Kojima

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Tohru Funahashi

²Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
Shinzo Miyamoto

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Jun Hokamaki

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Hirofumi Soejima

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Tomohiro Sakamoto

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Hiroaki Kawano

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Michihiro Yoshimura

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Akira Kitagawa

³Clinical Trial Management, Graduate School, International University of Health and Welfare, Tokyo, Japan
Yuji Matsuzawa

⁴Sumitomo Hospital, Osaka, Japan
Hisao Ogawa

¹Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Abstract

Summary

Adipose tissue is a secretory organ producing a variety of bioactive substances, such as adiponectin. Adiponectin has antiatherogenic properties while plasminogen activator inhibitor type 1 (PAI-1) is closely involved in the development of atherosclerosis. The relationship between adiponectin and PAI-1 in patients with coronary artery disease (CAD) has not been clarified. This study examined plasma levels of adiponectin and PAI-1 in 64 patients with stable exertional angina (SEA) and 65 patients with the chest pain syndrome (CPS). Plasma logadiponectin levels were significantly lower in patients with SEA (0.62±0.08 µg/dL) compared to those with CPS (0.86± 0.05 µg/dL) (p<0.0001). The plasma levels of log-PAI-1 were significantly higher in patients with SEA (1.23±0.18 ng/mL) compared to those with CPS (1.15±0.22 ng/mL) (p<0.05). Plasma log-adiponectin levels correlated negatively with diabetes mellitus (DM), body mass index (BMI), log-PAI-1 (r=−0.284, p<0.001), triglyceride (TG), and remnant-like particles cholesterol (RLP-C), and positively with high-density lipoprotein cholesterol (HDL-C) levels. Plasma levels of log-PAI-1 correlated positively with DM, BMI, TG and RLP-C levels, and negatively with HDL-C levels. Multiple logistic regression analysis identified sex, angina pectoris, and PAI-1 as independent determinants of hyperadiponectinemia (p<0.05). Adiponectin is inversely related to PAI-1. DM, BMI, TG, HDL-C, and RLP-C are common mediators between adiponectin and PAI-1, and treatment for common mediators may prevent the development of CAD by reducing PAI-1 and increasing adiponectin levels.

Keywords

Adiponectin - angina pectoris - fibrinolysis - plasminogen activator inhibitor type 1

Full Text

References

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