Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke

Justo Aznar; Yolanda Mira; Amparo Vayá; Dolores Corella; Fernando Ferrando; Piedad Villa; Amparo Estellés

doi:10.1160/TH03-11-0690

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 91(05): 1031-1034
DOI: 10.1160/TH03-11-0690

Cell Signaling and Vessel Remodeling

Schattauer GmbH

Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke

Justo Aznar

¹Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Yolanda Mira

¹Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Amparo Vayá

¹Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Dolores Corella

²Molecular Epidemiology Unit, School of Medicine University of Valencia, Spain

,

Fernando Ferrando

¹Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Piedad Villa

¹Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Amparo Estellés

³Research Center, La Fe University Hospital, Valencia, Spain

› Author Affiliations

Abstract

Summary

The association between factor V Leiden (FVL) and prothrombin G20210A (PT 20210) mutations and ischemic stroke remains controversial, particularly in young adults with cryptogenic stroke. Prevalence of FVL (4.1%) and PT 20210 (8.2%) mutations was assessed in 49 patients under 50 years with cryptogenic stroke and compared with controls. Odd ratio (OR) for cryptogenic stroke was 2.62 (95% CI, 0.49-13.95) for FVL and 3.75 (95% CI, 1.05-13.34) for PT 20210 and 3.28 (95% CI, 1,17-9.20) for some recognized genetic thrombophilic defect. Moreover, the OR for cryptogenic stroke in young women using oral contraceptives (OC) was 3.59 (95% CI, 1.28-10.5). When some genetic thrombophilic defect was associated with OC, the OR was much higher (OR: 14.27; 95% CI, 0.66-309.99). Our results suggest that in the Mediterranean populations the PT 20210 mutation, but not FV Leiden, is a risk factor for cryptogenic stroke in young adults. OC use is also a significant risk factor for cryptogenic stroke, which is increased in women with some genetic thrombotic risk factor.

Keywords

Stroke - factor V Leiden - prothrombin G20210A mutation - cryptogenic stroke - oral contraceptives

Full Text

References

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